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anti-CTGF antibody :: Rabbit anti-Human CTGF CTGF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535951 anti-CTGF antibody
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CTGF, Polyclonal Antibody

 Also Known As   

CTGF antibody

 Product Synonym Names    Polyclonal CTGF; Anti-CTGF; CCN2; HCS24; Hypertrophic chondrocyte-specific 24; Connective Tissue Growth Factor
 Product Gene Name   

anti-CTGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    121009
 3D Structure    ModBase 3D Structure for P29279
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human CTGF
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 Form/Format    Lyophilized from PBS, pH 7.2.
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 Biological Significance    CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF beta1, and BMP-4.
 Immunogen    CTGF antibody was raised in rabbit using highly pure recombinant human CTGF as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-CTGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CTGF antibody

   Affinity purified Rabbit polyclonal CTGF antibody
 Product Categories/Family for anti-CTGF antibody    Cytokines & Growth Factors; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-CTGF antibody   

ELISA (EIA), Inhibition, Western Blot (WB)

 Application Notes for anti-CTGF antibody    ELISA: 0.5-2 ug/ml
Inhibition: 6-9 ug/ml
WB: 0.1-0.2 ug/ml
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NCBI/Uniprot data below describe general gene information for CTGF. It may not necessarily be applicable to this product.
 NCBI GI #    4503123
 NCBI GeneID    1490
 NCBI Accession #    NP_001892.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001901.2 [Other Products]
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 UniProt Primary Accession #    P29279 [Other Products]
 UniProt Secondary Accession #    Q6LCY0; Q96A79; Q96QX2; Q9UDL6; E1P578 [Other Products]
 UniProt Related Accession #    P29279 [Other Products]
 Molecular Weight    11.2 kDa (predicted detection band MW)
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 NCBI Official Full Name    connective tissue growth factor
 NCBI Official Synonym Full Names    connective tissue growth factor
 NCBI Official Symbol    CTGF [Similar Products]
 NCBI Official Synonym Symbols   
CCN2; NOV2; HCS24; IGFBP8
[Similar Products]
 NCBI Protein Information    connective tissue growth factor
 UniProt Protein Name    Connective tissue growth factor
 UniProt Synonym Protein Names   
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
 Protein Family    Connective tissue growth factor
 UniProt Gene Name    CTGF [Similar Products]
 UniProt Synonym Gene Names    CCN2; HCS24; IGFBP8; IBP-8; IGF-binding protein 8; IGFBP-8 [Similar Products]
 UniProt Entry Name    CTGF_HUMAN
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 NCBI Summary for CTGF    The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CTGF    CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; extracellular region; cell cortex; cytosol

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding

Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of caspase activity; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of stress fiber formation; positive regulation of cell proliferation; tissue homeostasis; response to wounding; response to glucose stimulus; regulation of cell growth; angiogenesis; cell differentiation; cell adhesion; cartilage condensation; positive regulation of cell activation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; ossification; cell migration; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; positive regulation of protein amino acid phosphorylation; regulation of chondrocyte differentiation; positive regulation of cell differentiation; lung development
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 Research Articles on CTGF    1. increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor in encapsulating peritoneal sclerosis encapsulating peritoneal sclerosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CTGF antibodyPathways associated with anti-CTGF antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >688 publications with CTGF and TGFB1
 SMAD3 antibody  >160 publications with CTGF and SMAD3
 SMAD2 antibody  >144 publications with CTGF and SMAD2
 EGFR antibody  >43 publications with CTGF and EGFR
 VEGFA antibody  >28 publications with CTGF and VEGFA
 YAP1 antibody  >15 publications with CTGF and YAP1
 TGFBR2 antibody  >13 publications with CTGF and TGFBR2
 MMP3 antibody  >13 publications with CTGF and MMP3
 WWTR1 antibody  >11 publications with CTGF and WWTR1
 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-CTGF antibodyOrgans/Tissues associated with anti-CTGF antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1303 publications with CTGF and Fibrosis
 Kidney Diseases Antibodies  >365 publications with CTGF and Kidney Diseases
 Inflammation Antibodies  >306 publications with CTGF and Inflammation
 Cardiovascular Diseases Antibodies  >304 publications with CTGF and Cardiovascular Diseases
 Lung Diseases Antibodies  >201 publications with CTGF and Lung Diseases
 Liver Diseases Antibodies  >189 publications with CTGF and Liver Diseases
 Heart Diseases Antibodies  >187 publications with CTGF and Heart Diseases
 Hypertension Antibodies  >167 publications with CTGF and Hypertension
 Necrosis Antibodies  >156 publications with CTGF and Necrosis
 Pulmonary Fibrosis Antibodies  >150 publications with CTGF and Pulmonary Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >2674 publications with CTGF and Connective Tissue
 Muscle Antibodies  >641 publications with CTGF and Muscle
 Kidney Antibodies  >612 publications with CTGF and Kidney
 Blood Antibodies  >508 publications with CTGF and Blood
 Vascular Antibodies  >475 publications with CTGF and Vascular
 Lung Antibodies  >307 publications with CTGF and Lung
 Bone Antibodies  >299 publications with CTGF and Bone
 Liver Antibodies  >298 publications with CTGF and Liver
 Heart Antibodies  >289 publications with CTGF and Heart
 Skin Antibodies  >234 publications with CTGF and Skin
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