NP_001185706.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,492 Da
NCBI Official Full Name
cullin-2 isoform c
NCBI Official Synonym Full Names
cullin 2
NCBI Protein Information
cullin-2
UniProt Protein Name
Cullin-2
UniProt Synonym Gene Names
UniProt Entry Name
CUL2_HUMAN
UniProt Comments for CUL-2
CUL2: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Belongs to the cullin family.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10p11.21
Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; viral reproduction; protein ubiquitination; cell cycle arrest; G1/S transition of mitotic cell cycle
Research Articles on CUL-2
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Products associated with anti-CUL-2 antibody
Pathways associated with anti-CUL-2 antibody
Diseases associated with anti-CUL-2 antibody
Organs/Tissues associated with anti-CUL-2 antibody
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