Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CUL-4B rightarrow Polyclonal CUL-4B  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • TAFI ELISA Kit
 • X-Box Binding Protein 1 (XBP1) ELISA Kit
 • RAMP1 Antibody
 • Actin-related protein 2-3 complex subunit 4 (Arpc4) Recombinant Protein
 • Brain Derived Neurotrophic Factor (BDNF) Antibody
 • PLOD3 ELISA Kit
 • des-gamma-carboxy-prothromb in (DCP) ELISA Kit
 • Werner syndrome ATP-dependent helicase homolog (Wrn) Recombinant Protein
 • Muc19-Smgc Antibody
 • Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyl ... ELISA Kit
 • Regulator of G-protein signaling 2 (RGS2) Antibody
 • FANCM Antibody
 • Thyroid Stimulating Hormone Receptor (TSHR) ELISA Kit
 • A Disintegrin and Metalloprotease 29 (ADAM29) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CUL-4B antibody :: Rabbit CUL-4B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2537345
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CUL-4B, Polyclonal Antibody

 Also Known As   

CUL-4B Polyclonal Antibody

 Product Synonym Names    CUL4B; KIAA0695; Cullin-4B; CUL-4B
 Product Gene Name   

anti-CUL-4B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    300304
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
Section Bar
 Immunogen    Synthesized peptide derived from the Internal region of human CUL-4B.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Section Bar
 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CUL-4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-CUL-4B antibody    Cell biology
 Applications Tested/Suitable for anti-CUL-4B antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CUL-4B antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
Section Bar
 Western Blot (WB) of anti-CUL-4B antibody    Western Blot analysis of Mouse liver, Mouse kidney, Mouse heart with CUL-4B Polyclonal Antibody.
anti-CUL-4B antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-CUL-4B antibody    Immunohistochemistry of paraffin-embedded Rat brain tissue using CUL-4B Polyclonal Antibody at dilution of 1:100.
anti-CUL-4B antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CUL-4B. It may not necessarily be applicable to this product.
 NCBI GI #    121114302
 NCBI GeneID    8450
 NCBI Accession #    NP_001073341.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079872.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7; B1APK5; B3KVX4; B7Z5K8 [Other Products]
 UniProt Related Accession #    Q13620 [Other Products]
 Molecular Weight    Calculated MW: 102
Observed MW: 110
Table BarTOPTable Bar
 NCBI Official Full Name    cullin-4B isoform 2
 NCBI Official Synonym Full Names    cullin 4B
 NCBI Official Symbol    CUL4B [Similar Products]
 NCBI Official Synonym Symbols   
SFM2; MRXSC; CUL-4B; MRXHF2; MRXS15
[Similar Products]
 NCBI Protein Information    cullin-4B
 UniProt Protein Name    Cullin-4B
 UniProt Gene Name    CUL4B [Similar Products]
 UniProt Synonym Gene Names    KIAA0695; CUL-4B [Similar Products]
 UniProt Entry Name    CUL4B_HUMAN
Section Bar
 NCBI Summary for CUL-4B    This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CUL-4B    Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Table BarTOPTable Bar
 Research Articles on CUL-4B    1. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CUL-4B antibodyPathways associated with anti-CUL-4B antibody
 Reference Product  PubMed Publications
 CUL4A antibody  >34 publications with CUL-4B and CUL4A
 DDB1 antibody  >18 publications with CUL-4B and DDB1
 NEDD8 antibody  >7 publications with CUL-4B and NEDD8
 RBX1 antibody  >7 publications with CUL-4B and RBX1
 DTL antibody  >4 publications with CUL-4B and DTL
 DDB2 antibody  >3 publications with CUL-4B and DDB2
 CAND1 antibody  >3 publications with CUL-4B and CAND1
 COPS5 antibody  >1 publications with CUL-4B and COPS5
 Products by Pathway  Pathway Diagram
 Cul4-DDB1-CSA Complex Pathway antibodies  Cul4-DDB1-CSA Complex Pathway Diagram
 Cul4-DDB1-CSA Complex Pathway antibodies  Cul4-DDB1-CSA Complex Pathway Diagram
 Cul4-DDB1-DDB2 Complex Pathway antibodies  Cul4-DDB1-DDB2 Complex Pathway Diagram
 Cul4-DDB1-DDB2 Complex Pathway antibodies  Cul4-DDB1-DDB2 Complex Pathway Diagram
 DNA Damage Bypass Pathway antibodies  DNA Damage Bypass Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Dual Incision In GG-NER Pathway antibodies  Dual Incision In GG-NER Pathway Diagram
 Dual Incision In TC-NER Pathway antibodies  Dual Incision In TC-NER Pathway Diagram
 Formation Of Incision Complex In GG-NER Pathway antibodies  Formation Of Incision Complex In GG-NER Pathway Diagram
Diseases associated with anti-CUL-4B antibodyOrgans/Tissues associated with anti-CUL-4B antibody
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >15 publications with CUL-4B and Neurobehavioral Manifestations
 Neoplasms, Experimental Antibodies  >3 publications with CUL-4B and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >3 publications with CUL-4B and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with CUL-4B and Disease Models, Animal
 Liver Neoplasms Antibodies  >2 publications with CUL-4B and Liver Neoplasms
 Chromosome Aberrations Antibodies  >2 publications with CUL-4B and Chromosome Aberrations
 Breast Neoplasms Antibodies  >2 publications with CUL-4B and Breast Neoplasms
 Necrosis Antibodies  >2 publications with CUL-4B and Necrosis
 Liver Diseases Antibodies  >2 publications with CUL-4B and Liver Diseases
 Inflammation Antibodies  >2 publications with CUL-4B and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with CUL-4B and Brain
 Embryonic Tissue Antibodies  >7 publications with CUL-4B and Embryonic Tissue
 Nerve Antibodies  >5 publications with CUL-4B and Nerve
 Liver Antibodies  >4 publications with CUL-4B and Liver
 Blood Antibodies  >4 publications with CUL-4B and Blood
 Muscle Antibodies  >3 publications with CUL-4B and Muscle
 Heart Antibodies  >3 publications with CUL-4B and Heart
 Bone Antibodies  >3 publications with CUL-4B and Bone
 Testis Antibodies  >3 publications with CUL-4B and Testis
 Vascular Antibodies  >2 publications with CUL-4B and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions