NP_001008895.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 88 kDa Predicted: 88 kDa
NCBI Official Full Name
cullin-4A isoform 1
NCBI Official Synonym Full Names
cullin 4A
NCBI Protein Information
cullin-4A
UniProt Protein Name
Cullin-4A
UniProt Synonym Gene Names
NCBI Summary for CUL4A
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
UniProt Comments for CUL4A
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
Product References and Citations for anti-CUL4A antibody
Gong Y, Xiang XJ, Feng M, Chen J, Fang ZL, Xiong JP; Journal: Biologics. CUL4A promotes cell invasion in gastric cancer by activating the NF-kB signaling pathway.
Research Articles on CUL4A
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Products associated with anti-CUL4A antibody
Pathways associated with anti-CUL4A antibody
Diseases associated with anti-CUL4A antibody
Organs/Tissues associated with anti-CUL4A antibody
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