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anti-CX3CR1 antibody :: Rabbit anti-Human CX3CR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150820
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CX3CR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CX3CR1 Antibody

 Product Synonym Names    CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1
 Product Gene Name   

anti-CX3CR1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CX3CR1 peptide (MBS152040) is used for blocking the activity of CX3CR1 antibody (MBS150820)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 613784
 3D Structure    ModBase 3D Structure for P49238
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    At least two isoforms of CX3CR1 are known to exist.
 Purity/Purification    CX3CR1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CX3CR1 antibody was raised against a peptide corresponding to amino acids in a extracellular loop of human CX3CR1.
 Buffer    CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CX3CR1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CX3CR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CX3CR1 antibody

   CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was initially identified as the receptor for the transmembrane molecule fractalkine, and renamed CX3CR1. CX3CR1 is known to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.
 Applications Tested/Suitable for anti-CX3CR1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CX3CR1 antibody    CX3CR1 antibody can be used for detection of CX3CR1 by Western blot at 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-CX3CR1 antibody    Western blot analysis of CX3CR1 in THP-1 cell lysate with CX3CR1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-CX3CR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CX3CR1 antibody    Immunohistochemistry of CX3CR1 in human spleen cells with CX3CR1 antibody at 10 μg/mL.
anti-CX3CR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CX3CR1 antibody    Immunofluorescence of CX3CR1 in THP-1 cells with CX3CR1 antibody at 20 μg/mL.
anti-CX3CR1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CX3CR1. It may not necessarily be applicable to this product.
 NCBI GI #    4503171
 NCBI GeneID    1524
 NCBI Accession #    NP_001328 [Other Products]
 NCBI GenBank Nucleotide #    NM_001337.3 [Other Products]
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 UniProt Primary Accession #    P49238 [Other Products]
 UniProt Secondary Accession #    A0N0N6; B2R5Z4; J3KP17 [Other Products]
 UniProt Related Accession #    P49238 [Other Products]
 Molecular Weight    Predicted: 39; 43 kDa

Observed: 50 kDa
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 NCBI Official Full Name    CX3C chemokine receptor 1 isoform b
 NCBI Official Synonym Full Names    chemokine (C-X3-C motif) receptor 1
 NCBI Official Symbol    CX3CR1 [Similar Products]
 NCBI Official Synonym Symbols   
V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1
[Similar Products]
 NCBI Protein Information    CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1
 UniProt Protein Name    CX3C chemokine receptor 1
 UniProt Synonym Protein Names   
Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
 Protein Family    CX3C chemokine receptor
 UniProt Gene Name    CX3CR1 [Similar Products]
 UniProt Synonym Gene Names    CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1 [Similar Products]
 UniProt Entry Name    CX3C1_HUMAN
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 NCBI Summary for CX3CR1    Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for CX3CR1    CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Cell adhesion; Receptor, cytokine; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; macrophage chemotaxis; negative regulation of cell migration; microglial cell activation during immune response

Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on CX3CR1    1. The damaging rs3732378 variant in the CX3CR1 chemokine receptor was shared by all affected family members and by 15% of 28 sporadic hip dysplastics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CX3CR1 antibodyPathways associated with anti-CX3CR1 antibody
 Reference Product  PubMed Publications
 CX3CL1 antibody  >475 publications with CX3CR1 and CX3CL1
 CCL2 antibody  >120 publications with CX3CR1 and CCL2
 CXCL12 antibody  >41 publications with CX3CR1 and CXCL12
 CCL5 antibody  >38 publications with CX3CR1 and CCL5
 CXCL10 antibody  >18 publications with CX3CR1 and CXCL10
 CCL17 antibody  >6 publications with CX3CR1 and CCL17
 CCL22 antibody  >6 publications with CX3CR1 and CCL22
 CCL21 antibody  >4 publications with CX3CR1 and CCL21
 CCL26 antibody  >4 publications with CX3CR1 and CCL26
 CCL13 antibody  >1 publications with CX3CR1 and CCL13
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-CX3CR1 antibodyOrgans/Tissues associated with anti-CX3CR1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >326 publications with CX3CR1 and Inflammation
 Nervous System Diseases Antibodies  >193 publications with CX3CR1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >166 publications with CX3CR1 and Disease Models, Animal
 Necrosis Antibodies  >110 publications with CX3CR1 and Necrosis
 Atherosclerosis Antibodies  >94 publications with CX3CR1 and Atherosclerosis
 HIV Infections Antibodies  >51 publications with CX3CR1 and HIV Infections
 Kidney Diseases Antibodies  >41 publications with CX3CR1 and Kidney Diseases
 Coronary Disease Antibodies  >36 publications with CX3CR1 and Coronary Disease
 Liver Diseases Antibodies  >32 publications with CX3CR1 and Liver Diseases
 Fibrosis Antibodies  >26 publications with CX3CR1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >502 publications with CX3CR1 and Blood
 Brain Antibodies  >213 publications with CX3CR1 and Brain
 Lung Antibodies  >72 publications with CX3CR1 and Lung
 Kidney Antibodies  >65 publications with CX3CR1 and Kidney
 Spinal Cord Antibodies  >57 publications with CX3CR1 and Spinal Cord
 Liver Antibodies  >47 publications with CX3CR1 and Liver
 Spleen Antibodies  >22 publications with CX3CR1 and Spleen
 Connective Tissue Antibodies  >15 publications with CX3CR1 and Connective Tissue
 Pancreas Antibodies  >13 publications with CX3CR1 and Pancreas
 Thymus Antibodies  >11 publications with CX3CR1 and Thymus
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