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anti-IL8RA antibody :: Goat CXCR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422389 anti-IL8RA antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR1 (IL8RA), Polyclonal Antibody

 Also Known As   

Goat anti-CXCR1 Antibody

 Product Synonym Names    Goat Anti-CXCR1 (aa26-38) Antibody; IL8RA; interleukin 8 receptor, alpha; C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXCR1; IL8R1; IL8RBA; IL-8 receptor type 1; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor alpha; interleukin-8; C-C antibody; C-C-CKR-1 antibody; CD128 antibody; CD181 antibody; CDw128a antibody; chemokine (C-X-C motif) receptor 1 antibody; CKR-1 antibody; CMKAR1 antibody; CXCR1 antibody; IL-8 receptor type 1 antibody; IL8R1 antibody; IL8RBA antibody; interleukin 8 receptor alpha antibody; interleukin 8 receptor; alpha antibody; IL8RA antibody
 Product Gene Name   

anti-IL8RA antibody

[Similar Products]
 Product Synonym Gene Name    CXCR1 [Similar Products]
 Antibody/Peptide Pairs    CXCR1 peptide (MBS427310) is used for blocking the activity of CXCR1 antibody (MBS422389)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SKEFLARHRV TSY
 OMIM    146929
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SKEFLARHRVTSY, from the C Terminus of the protein sequence according to NP_000625.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-IL8RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IL8RA antibody   

Peptide ELISA (EIA)

 Application Notes for anti-IL8RA antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments gave an approx 100kDa band in Human Peripharal Blood Mononucleocytes lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 39.8kDa according to NP_000625.1. The 100kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for IL8RA. It may not necessarily be applicable to this product.
 NCBI GI #    4504681
 NCBI GeneID    3577
 NCBI Accession #    NP_000625.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000634.2 [Other Products]
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 UniProt Secondary Accession #    Q2YEF8; Q2YEG4; Q2YEG5; Q2YEG7; Q2YEG8; Q53R18; Q6IN95; Q8N6T6; Q9P2T8; Q9P2T9; B2R6Q3 [Other Products]
 UniProt Related Accession #    P25024 [Other Products]
 Molecular Weight    39,791 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 1
 NCBI Official Synonym Full Names    C-X-C motif chemokine receptor 1
 NCBI Official Symbol    CXCR1 [Similar Products]
 NCBI Official Synonym Symbols   
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 1
 UniProt Protein Name    C-X-C chemokine receptor type 1
 UniProt Synonym Protein Names   
CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181
 UniProt Gene Name    CXCR1 [Similar Products]
 UniProt Synonym Gene Names    CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A [Similar Products]
 UniProt Entry Name    CXCR1_HUMAN
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 NCBI Summary for IL8RA    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL8RA    IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, cytokine; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: chemokine receptor activity; G-protein coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity

Biological Process: cell surface receptor linked signal transduction; chemotaxis; dendritic cell chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; receptor internalization

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on IL8RA    1. In HCC cell lines, IL8 activates expression of FOXC1 via the phosphoinositide 3-kinase signaling to AKT and hypoxia-inducible factor 1alpha. FOXC1 expression leads to transactivation of CXCR1 and CCL2, promoting inflammation and invasivion/metastasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL8RA antibodyPathways associated with anti-IL8RA antibody
 Reference Product  PubMed Publications
 CXCR2 antibody  >566 publications with IL8RA and CXCR2
 CXCL1 antibody  >123 publications with IL8RA and CXCL1
 IL8 antibody  >62 publications with IL8RA and IL8
 CCL5 antibody  >39 publications with IL8RA and CCL5
 CXCL2 antibody  >31 publications with IL8RA and CXCL2
 CXCL5 antibody  >27 publications with IL8RA and CXCL5
 CXCL6 antibody  >23 publications with IL8RA and CXCL6
 CXCL3 antibody  >10 publications with IL8RA and CXCL3
 PPBP antibody  >6 publications with IL8RA and PPBP
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Diseases associated with anti-IL8RA antibodyOrgans/Tissues associated with anti-IL8RA antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >263 publications with IL8RA and Inflammation
 Lung Diseases Antibodies  >89 publications with IL8RA and Lung Diseases
 Necrosis Antibodies  >79 publications with IL8RA and Necrosis
 Skin Diseases Antibodies  >51 publications with IL8RA and Skin Diseases
 Disease Models, Animal Antibodies  >45 publications with IL8RA and Disease Models, Animal
 Nervous System Diseases Antibodies  >40 publications with IL8RA and Nervous System Diseases
 Adenocarcinoma Antibodies  >26 publications with IL8RA and Adenocarcinoma
 Kidney Diseases Antibodies  >23 publications with IL8RA and Kidney Diseases
 Neoplasm Invasiveness Antibodies  >22 publications with IL8RA and Neoplasm Invasiveness
 Fibrosis Antibodies  >20 publications with IL8RA and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >450 publications with IL8RA and Blood
 Lung Antibodies  >105 publications with IL8RA and Lung
 Brain Antibodies  >46 publications with IL8RA and Brain
 Bone Antibodies  >43 publications with IL8RA and Bone
 Liver Antibodies  >36 publications with IL8RA and Liver
 Bone Marrow Antibodies  >29 publications with IL8RA and Bone Marrow
 Intestine Antibodies  >19 publications with IL8RA and Intestine
 Heart Antibodies  >17 publications with IL8RA and Heart
 Spleen Antibodies  >14 publications with IL8RA and Spleen
 Thymus Antibodies  >7 publications with IL8RA and Thymus
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