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anti-CXCR2 antibody :: Rabbit anti-Human CXCR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002022
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CXCR2 Antibody

 Product Synonym Names    C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD182; CXCR2; IL8RB
 Product Gene Name   

anti-CXCR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146928
 3D Structure    ModBase 3D Structure for P25025
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human C-X-C chemokine receptor type 2 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22661 / sc-682 / sc-683
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CXCR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCR2 antibody

   Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
 Applications Tested/Suitable for anti-CXCR2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-CXCR2 antibody    Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7002022 at dilution of 1:100
anti-CXCR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CXCR2 antibody    Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7002022 at dilution of 1:100
anti-CXCR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CXCR2 antibody    Immunofluorescent analysis of HepG2 cells using MBS7002022 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CXCR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CXCR2. It may not necessarily be applicable to this product.
 NCBI GI #    269973859
 NCBI GeneID    3579
 NCBI Accession #    NP_001161770.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168298.1 [Other Products]
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 UniProt Primary Accession #    P25025 [Other Products]
 UniProt Secondary Accession #    Q8IUZ1; Q9P2T6; Q9P2T7 [Other Products]
 UniProt Related Accession #    P25025; AAB24742; AAA15417 [Other Products]
 Molecular Weight    40,759 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 2
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 2
 NCBI Official Symbol    CXCR2 [Similar Products]
 NCBI Official Synonym Symbols   
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 2
 UniProt Protein Name    C-X-C chemokine receptor type 2
 UniProt Synonym Protein Names   
CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen: CD182
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR2 [Similar Products]
 UniProt Synonym Gene Names    IL8RB; CXC-R2; CXCR-2; IL-8R B [Similar Products]
 UniProt Entry Name    CXCR2_HUMAN
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 NCBI Summary for CXCR2    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CXCR2    IL-8R B: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Receptor, cytokine; GPCR, family 1

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cell surface; cytosol; integral to plasma membrane; intracellular; mast cell granule; membrane; plasma membrane

Molecular Function: C-X-C chemokine receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding; signal transducer activity

Biological Process: acute inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; cellular defense response; chemotaxis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; midbrain development; negative regulation of neutrophil apoptosis; neutrophil activation; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of vascular permeability; receptor internalization; signal transduction
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 Research Articles on CXCR2    1. we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 and CXCR4, were hypomethylated after 5-aza treatment
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCR2 antibodyPathways associated with anti-CXCR2 antibody
 Reference Product  PubMed Publications
 CXCL1 antibody  >364 publications with CXCR2 and CXCL1
 CXCL2 antibody  >172 publications with CXCR2 and CXCL2
 CXCL5 antibody  >95 publications with CXCR2 and CXCL5
 IL8 antibody  >85 publications with CXCR2 and IL8
 CXCL12 antibody  >72 publications with CXCR2 and CXCL12
 CXCL6 antibody  >27 publications with CXCR2 and CXCL6
 CXCL3 antibody  >14 publications with CXCR2 and CXCL3
 PPBP antibody  >12 publications with CXCR2 and PPBP
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Diseases associated with anti-CXCR2 antibodyOrgans/Tissues associated with anti-CXCR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >565 publications with CXCR2 and Inflammation
 Lung Diseases Antibodies  >209 publications with CXCR2 and Lung Diseases
 Disease Models, Animal Antibodies  >192 publications with CXCR2 and Disease Models, Animal
 Necrosis Antibodies  >145 publications with CXCR2 and Necrosis
 Nervous System Diseases Antibodies  >101 publications with CXCR2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >98 publications with CXCR2 and Cardiovascular Diseases
 Lung Injury Antibodies  >74 publications with CXCR2 and Lung Injury
 Sepsis Antibodies  >66 publications with CXCR2 and Sepsis
 Hypersensitivity Antibodies  >58 publications with CXCR2 and Hypersensitivity
 Asthma Antibodies  >57 publications with CXCR2 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >844 publications with CXCR2 and Blood
 Lung Antibodies  >279 publications with CXCR2 and Lung
 Bone Antibodies  >142 publications with CXCR2 and Bone
 Brain Antibodies  >114 publications with CXCR2 and Brain
 Heart Antibodies  >49 publications with CXCR2 and Heart
 Intestine Antibodies  >48 publications with CXCR2 and Intestine
 Spleen Antibodies  >35 publications with CXCR2 and Spleen
 Prostate Antibodies  >30 publications with CXCR2 and Prostate
 Connective Tissue Antibodies  >28 publications with CXCR2 and Connective Tissue
 Placenta Antibodies  >6 publications with CXCR2 and Placenta
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