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anti-CXCR3 antibody :: Goat CXCR3/GPR9 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420390 anti-CXCR3 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR3/GPR9, Polyclonal Antibody

 Also Known As   

Goat anti-CXCR3/GPR9 Antibody

 Product Synonym Names    CXCR3; chemokine (C-X-C motif) receptor 3; HGNC: 4540; CD183; CKR-L2; CMKAR3; GPR9; IP10; IP10-R; Mig-R; MigR; G protein-coupled receptor 9; IP10 receptor; Mig receptor; chemokine (C-X-C) receptor 3; CXCR3 antibody; chemokine (C-X-C motif) receptor 3 antibody; HGNC: 4540 antibody; CD183 antibody; CKR-L2 antibody; CMKAR3 antibody; GPR9 antibody; IP10 antibody; IP10-R antibody; Mig-R antibody; MigR antibody; G protein-coupled receptor 9 antibody; IP10 receptor antibody; Mig receptor antibody; chemokine (C-X-C) receptor 3 antibody; CXCR3 / GPR9
 Product Gene Name   

anti-CXCR3 antibody

[Similar Products]
 Product Synonym Gene Name    GPR9 [Similar Products]
 Antibody/Peptide Pairs    CXCR3 / GPR9 peptide (MBS426722) is used for blocking the activity of CXCR3/GPR9 antibody (MBS420390)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RRDSSWSETS EA
 OMIM    300574
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RRDSSWSETSEA, from the C Terminus of the protein sequence according to NP_001495.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CXCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CXCR3 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-CXCR3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave an approx 50-55kDa band in lysates of human thymus, kidney and placenta, and of cell line HeLa after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 40.7kDa according to NP_001495.1. The 50-55kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.
 NCBI GI #    4504099
 NCBI GeneID    2833
 NCBI Accession #    NP_001495.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001504.1 [Other Products]
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 UniProt Secondary Accession #    O15185; Q7Z710; Q9P2T4; Q9P2T5; B2R982 [Other Products]
 UniProt Related Accession #    P49682 [Other Products]
 Molecular Weight    28,715 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 3 isoform 1
 NCBI Official Synonym Full Names    C-X-C motif chemokine receptor 3
 NCBI Official Symbol    CXCR3 [Similar Products]
 NCBI Official Synonym Symbols   
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 3
 UniProt Protein Name    C-X-C chemokine receptor type 3
 UniProt Synonym Protein Names   
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR3 [Similar Products]
 UniProt Synonym Gene Names    GPR9; CXC-R3; CXCR-3; IP-10 receptor [Similar Products]
 UniProt Entry Name    CXCR3_HUMAN
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 NCBI Summary for CXCR3    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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 UniProt Comments for CXCR3    CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: cytoplasm; cytosol; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine binding; chemokine receptor activity; receptor activity

Biological Process: angiogenesis; apoptosis; calcium-mediated signaling; cell adhesion; cell motility; cell surface receptor linked signal transduction; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of angiogenesis; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of leukocyte migration
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 Research Articles on CXCR3    1. CXCR3-A, the predominant form in hematopoietic cells, mediates tumor "go" signaling by promoting cell proliferation, survival, chemotaxis, invasion and metastasis; while CXCR3-B, on epithelial cells, mediates "stop" signaling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCR3 antibodyPathways associated with anti-CXCR3 antibody
 Reference Product  PubMed Publications
 CXCL10 antibody  >962 publications with CXCR3 and CXCL10
 CXCL9 antibody  >545 publications with CXCR3 and CXCL9
 CXCL11 antibody  >356 publications with CXCR3 and CXCL11
 CCL5 antibody  >169 publications with CXCR3 and CCL5
 CXCL12 antibody  >140 publications with CXCR3 and CXCL12
 CCL21 antibody  >54 publications with CXCR3 and CCL21
 CXCL13 antibody  >32 publications with CXCR3 and CXCL13
 CCL19 antibody  >30 publications with CXCR3 and CCL19
 CCL11 antibody  >27 publications with CXCR3 and CCL11
 PF4 antibody  >14 publications with CXCR3 and PF4
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CXCR3 antibodyOrgans/Tissues associated with anti-CXCR3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >651 publications with CXCR3 and Inflammation
 Autoimmune Diseases Antibodies  >347 publications with CXCR3 and Autoimmune Diseases
 Necrosis Antibodies  >224 publications with CXCR3 and Necrosis
 Lung Diseases Antibodies  >197 publications with CXCR3 and Lung Diseases
 Hypersensitivity Antibodies  >146 publications with CXCR3 and Hypersensitivity
 Liver Diseases Antibodies  >138 publications with CXCR3 and Liver Diseases
 Carcinoma Antibodies  >119 publications with CXCR3 and Carcinoma
 Cardiovascular Diseases Antibodies  >109 publications with CXCR3 and Cardiovascular Diseases
 Fibrosis Antibodies  >90 publications with CXCR3 and Fibrosis
 Death Antibodies  >89 publications with CXCR3 and Death
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1646 publications with CXCR3 and Blood
 Brain Antibodies  >154 publications with CXCR3 and Brain
 Spleen Antibodies  >131 publications with CXCR3 and Spleen
 Intestine Antibodies  >78 publications with CXCR3 and Intestine
 Muscle Antibodies  >68 publications with CXCR3 and Muscle
 Connective Tissue Antibodies  >18 publications with CXCR3 and Connective Tissue
 Uncharacterized Tissue Antibodies  >2 publications with CXCR3 and Uncharacterized Tissue
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