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anti-CXCR3 antibody :: Rabbit anti-Human CXCR3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS247354
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR3, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human CXCR3

 Product Synonym Names    Anti-CXCR3 Antibody (aa161-210) IHC-plus; CXCR3; C-x-c chemokine receptor 3; CD183 antigen; CKR-L2; CXCR-3; CMKAR3; CD182; CD183; Cxcr3a; GPR9; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R; Chemokine (C-X-C) receptor 3; CXC-R3; Cxcr3b; G protein-coupled receptor 9; IP10 receptor; Human CXCR3
 Product Gene Name   

anti-CXCR3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300574
 3D Structure    ModBase 3D Structure for P49682
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    CXCR3 Antibody detects endogenous levels of total CXCR3 protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human CXCR3 (aa161-210).
 Immunogen    CXCR3 antibody was raised against synthetic peptide from human CXCR3 (aa161-210).
 Antigen Modification    aa161-210
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CXCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCR3 antibody

   CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000).
 Product Categories/Family for anti-CXCR3 antibody    Family: GPCR
Subfamily: Chemokine
 Applications Tested/Suitable for anti-CXCR3 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CXCR3 antibody    ELISA (1:5000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-CXCR3 antibody    Anti-CXCR3 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CXCR3 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CXCR3 antibody    Western blot of extracts from K562 cells, using CXCR3 Antibody. The lane on the right is treated with the synthesized peptide.
anti-CXCR3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.
 NCBI GI #    4504099
 NCBI GeneID    2833
 NCBI Accession #    NP_001495.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001504.1 [Other Products]
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 UniProt Primary Accession #    P49682 [Other Products]
 UniProt Secondary Accession #    O15185; Q7Z710; Q9P2T4; Q9P2T5; B2R982 [Other Products]
 UniProt Related Accession #    P49682 [Other Products]
 Molecular Weight    28,715 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 3 isoform 1
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 3
 NCBI Official Symbol    CXCR3 [Similar Products]
 NCBI Official Synonym Symbols   
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor
 UniProt Protein Name    C-X-C chemokine receptor type 3
 UniProt Synonym Protein Names   
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR3 [Similar Products]
 UniProt Synonym Gene Names    GPR9; CXC-R3; CXCR-3; IP-10 receptor [Similar Products]
 UniProt Entry Name    CXCR3_HUMAN
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 NCBI Summary for CXCR3    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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 UniProt Comments for CXCR3    CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: C-X-C chemokine binding; chemokine binding; chemokine receptor activity; receptor activity; C-X-C chemokine receptor activity

Biological Process: apoptosis; positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; negative regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; negative regulation of endothelial cell proliferation; regulation of leukocyte migration; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; cell motility; cell adhesion
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 Research Articles on CXCR3    1. plays a role in insulin resistance and obesity-induced visceral adipose inflammation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCR3 antibodyPathways associated with anti-CXCR3 antibody
 Reference Product  PubMed Publications
 CXCL10 antibody  >815 publications with CXCR3 and CXCL10
 CD4 antibody  >628 publications with CXCR3 and CD4
 CXCL9 antibody  >466 publications with CXCR3 and CXCL9
 CXCL11 antibody  >301 publications with CXCR3 and CXCL11
 CCL5 antibody  >146 publications with CXCR3 and CCL5
 CXCL13 antibody  >28 publications with CXCR3 and CXCL13
 CCL11 antibody  >25 publications with CXCR3 and CCL11
 PF4 antibody  >14 publications with CXCR3 and PF4
 CCL7 antibody  >10 publications with CXCR3 and CCL7
 CCL13 antibody  >3 publications with CXCR3 and CCL13
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with anti-CXCR3 antibodyOrgans/Tissues associated with anti-CXCR3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >573 publications with CXCR3 and Inflammation
 Autoimmune Diseases Antibodies  >313 publications with CXCR3 and Autoimmune Diseases
 Necrosis Antibodies  >203 publications with CXCR3 and Necrosis
 Lung Diseases Antibodies  >183 publications with CXCR3 and Lung Diseases
 Hypersensitivity Antibodies  >139 publications with CXCR3 and Hypersensitivity
 Liver Diseases Antibodies  >120 publications with CXCR3 and Liver Diseases
 Carcinoma Antibodies  >107 publications with CXCR3 and Carcinoma
 Cardiovascular Diseases Antibodies  >95 publications with CXCR3 and Cardiovascular Diseases
 Fibrosis Antibodies  >78 publications with CXCR3 and Fibrosis
 Death Antibodies  >72 publications with CXCR3 and Death
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1478 publications with CXCR3 and Blood
 Brain Antibodies  >139 publications with CXCR3 and Brain
 Spleen Antibodies  >119 publications with CXCR3 and Spleen
 Intestine Antibodies  >69 publications with CXCR3 and Intestine
 Muscle Antibodies  >55 publications with CXCR3 and Muscle
 Connective Tissue Antibodies  >15 publications with CXCR3 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with CXCR3 and Uncharacterized Tissue
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