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anti-CXCR4 antibody :: Rabbit anti-Human, Mouse CXCR4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151360
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR4, Polyclonal Antibody

★Popular Item★
 Also Known As   

CXCR4 Antibody

 Product Synonym Names    CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; chemokine (C-X-C motif) receptor 4
 Product Gene Name   

anti-CXCR4 antibody

[Similar Products]
 Antibody/Peptide Pairs    CXCR4 peptide (MBS153008) is used for blocking the activity of CXCR4 antibody (MBS151360)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 193670
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    CXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.
 Purity/Purification    CXCR4 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CXCR4 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4.
 Buffer    CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CXCR4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CXCR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCR4 antibody

   CXCR4 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
 Applications Tested/Suitable for anti-CXCR4 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

 Application Notes for anti-CXCR4 antibody    CXCR4 antibody can be used for Western blot at 1 - 2 mug/mL dilution and for immunoprecipitation and immunocytochemistry at 10 mug/mL. Immunofluorescence starting at 20 mug/mL. Flow Cytometry at 0.1 mug/ml
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 Western Blot (WB) of anti-CXCR4 antibody    Western blot analysis of CXCR4 in HeLa whole cell lysate with CXCR4 antibody at 0.5 μg/mL.
anti-CXCR4 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-CXCR4 antibody    Immunocytochemistry of CXCR4 in HeLa cells with CXCR4 antibody at 2 μg/mL.
anti-CXCR4 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-CXCR4 antibody    Immunofluorescence of CXCR4 in HeLa cells with CXCR4 antibody at 20 μg/mL.
anti-CXCR4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CXCR4. It may not necessarily be applicable to this product.
 NCBI GI #    4503175
 NCBI GeneID    7852
 NCBI Accession #    NP_003458 [Other Products]
 NCBI GenBank Nucleotide #    NM_003467.2 [Other Products]
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 UniProt Secondary Accession #    O60835; P30991; P56438; Q53S69; Q9BXA0; Q9UKN2; B2R5N0 [Other Products]
 UniProt Related Accession #    P61073 [Other Products]
 Molecular Weight    40,221 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 4 isoform b
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 4
 NCBI Official Symbol    CXCR4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor
 UniProt Protein Name    C-X-C chemokine receptor type 4
 UniProt Synonym Protein Names   
FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR4 [Similar Products]
 UniProt Synonym Gene Names    CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor [Similar Products]
 UniProt Entry Name    CXCR4_HUMAN
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 NCBI Summary for CXCR4    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CXCR4    CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q21

Cellular Component: cell surface; lysosome; cytoplasmic membrane-bound vesicle; early endosome; leading edge; integral to membrane; intercellular junction; growth cone; cytoplasm; late endosome; plasma membrane; cytoplasmic vesicle; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; viral receptor activity; ubiquitin binding; protein binding; cytokine binding; ubiquitin protein ligase binding; coreceptor activity; myosin light chain binding; actin binding; C-X-C chemokine receptor activity

Biological Process: entry of virus into host cell; regulation of chemotaxis; neutrophil activation; viral reproduction; apoptosis; activation of MAPK activity; response to virus; neuron migration; calcium-mediated signaling; motor axon guidance; regulation of cell migration; germ cell development; patterning of blood vessels; T cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; ameboidal cell migration; germ cell migration; myelin maintenance; response to hypoxia; dendritic cell chemotaxis; entry into host cell; positive regulation of oligodendrocyte differentiation; brain development; inflammatory response

Disease: Whim Syndrome
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 Research Articles on CXCR4    1. Translocation kinetics and modelling indicates CXCR4 endocytosis rate regulates surface expression of CXCR4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CXCR4 antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
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