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anti-CXXC5 antibody :: Rabbit CXXC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150962
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXXC5, Polyclonal Antibody

 Also Known As   

CXXC5 Antibody

 Product Synonym Names    CXXC5; CF5; WID; RINF; HSPC195; CXXC-type zinc finger protein 5; Putative MAPK-activating protein PM08; CF5; CXXC finger protein 5
 Product Gene Name   

anti-CXXC5 antibody

[Similar Products]
 Antibody/Peptide Pairs    CXXC5 peptide (MBS153075) is used for blocking the activity of CXXC5 antibody (MBS150962)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612752
 3D Structure    ModBase 3D Structure for Q7LFL8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two isoforms of CXXC5 are known to exist. CXXC5 antibody is predicted to not cross-react with other CXXC protein family members.
 Purity/Purification    CXXC5 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CXXC5 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human CXXC5.
 Buffer    CXXC5 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CXXC5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CXXC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CXXC5 antibody

   CXXC5 Antibody: CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development.
 Applications Tested/Suitable for anti-CXXC5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CXXC5 antibody    CXXC5 antibody can be used for detection of CXXC5 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-CXXC5 antibody    Western blot analysis of CXXC5 in human brain tissue lysate with CXXC5 antibody at 1 μg/mL.
anti-CXXC5 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CXXC5 antibody    Immunofluorescence of CXXC5 in Human Brain cells with CXXC5 antibody at 20 μg/mL.
anti-CXXC5 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-CXXC5 antibody    Immunohistochemistry of CXXC5 in human brain tissue with CXXC5 antibody at 2.5 μg/mL.
anti-CXXC5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CXXC5. It may not necessarily be applicable to this product.
 NCBI GI #    158261990
 NCBI GeneID    51523
 NCBI Accession #    NP_057547 [Other Products]
 NCBI GenBank Nucleotide #    NM_016463.7 [Other Products]
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 UniProt Primary Accession #    Q7LFL8 [Other Products]
 UniProt Secondary Accession #    Q8TB79; Q9NV51; Q9P0S8; B3KND0; C8CBA8 [Other Products]
 UniProt Related Accession #    Q7LFL8 [Other Products]
 Molecular Weight    24,072 Da
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 NCBI Official Full Name    CXXC-type zinc finger protein 5
 NCBI Official Synonym Full Names    CXXC finger protein 5
 NCBI Official Symbol    CXXC5 [Similar Products]
 NCBI Official Synonym Symbols   
CF5; WID; RINF; HSPC195
[Similar Products]
 NCBI Protein Information    CXXC-type zinc finger protein 5; CXXC finger 5 protein; retinoid-inducible nuclear factor; WT1-induced Inhibitor of Dishevelled; putative MAPK-activating protein PM08; putative NF-kappa-B-activating protein 102
 UniProt Protein Name    CXXC-type zinc finger protein 5
 UniProt Synonym Protein Names   
Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF
 Protein Family    CXXC-type zinc finger protein
 UniProt Gene Name    CXXC5 [Similar Products]
 UniProt Synonym Gene Names    CF5; RINF [Similar Products]
 UniProt Entry Name    CXXC5_HUMAN
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 UniProt Comments for CXXC5    CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: signal transducer activity; DNA binding; zinc ion binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction
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 Research Articles on CXXC5    1. targeting of CXXC5/RINF should be considered as a possible therapeutic strategy, especially in high-risk patients who show increased expression in AML cells compared with normal hematopoietic cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXXC5 antibodyDiseases associated with anti-CXXC5 antibody
 Reference Product  PubMed Publications
 BMP4 antibody  >2 publications with CXXC5 and BMP4
 WNT3A antibody  >1 publications with CXXC5 and WNT3A
 AXIN2 antibody  >1 publications with CXXC5 and AXIN2
 ATM antibody  >1 publications with CXXC5 and ATM
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >2 publications with CXXC5 and Heart Diseases
 Prostatic Neoplasms Antibodies  >1 publications with CXXC5 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >1 publications with CXXC5 and Prostatic Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CXXC5 and Cardiovascular Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with CXXC5 and Abnormalities, Drug-Induced
 Hypertrophy Antibodies  >1 publications with CXXC5 and Hypertrophy
 Disease Models, Animal Antibodies  >1 publications with CXXC5 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with CXXC5 and Necrosis
Organs/Tissues associated with anti-CXXC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with CXXC5 and Bone
 Heart Antibodies  >4 publications with CXXC5 and Heart
 Ovary Antibodies  >4 publications with CXXC5 and Ovary
 Muscle Antibodies  >4 publications with CXXC5 and Muscle
 Blood Antibodies  >2 publications with CXXC5 and Blood
 Kidney Antibodies  >2 publications with CXXC5 and Kidney
 Connective Tissue Antibodies  >2 publications with CXXC5 and Connective Tissue
 Brain Antibodies  >2 publications with CXXC5 and Brain
 Skin Antibodies  >1 publications with CXXC5 and Skin
 Intestine Antibodies  >1 publications with CXXC5 and Intestine
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