NP_000092.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytochrome b-245 light chain
NCBI Official Synonym Full Names
cytochrome b-245, alpha polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
cytochrome b-245 light chain; p22phox; cytochrome b light chain; p22 phagocyte B-cytochrome; cytochrome b(558) alpha chain; cytochrome b558 subunit alpha; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; flavocytochrome b-558 alpha polypeptide; neutrophil cytochrome b 22 kDa polypeptide; superoxide-generating NADPH oxidase light chain subunit
UniProt Protein Name
Cytochrome b-245 light chain
UniProt Synonym Protein Names
Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox
UniProt Synonym Gene Names
UniProt Entry Name
CY24A_HUMAN
NCBI Summary for CYBA
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
UniProt Comments for CYBA
CYBA: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family.
Protein type: EC 1.-.-.-; Oxidoreductase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: Golgi apparatus; phagocytic vesicle membrane; membrane; cell soma; mitochondrion; dendrite; apical plasma membrane; plasma membrane; endosome; secretory granule; NADPH oxidase complex
Molecular Function: protein binding; electron carrier activity; protein heterodimerization activity; superoxide-generating NADPH oxidase activity; metal ion binding; heme binding; SH3 domain binding
Biological Process: respiratory burst; response to nutrient levels; response to drug; interaction with host; angiotensin-mediated regulation of glomerular filtration; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; regulation of release of sequestered calcium ion into cytosol; antigen processing and presentation of peptide antigen via MHC class I; cytochrome complex assembly; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; smooth muscle hypertrophy; positive regulation of endothelial cell proliferation; inflammatory response; vascular endothelial growth factor receptor signaling pathway; superoxide release; hydrogen peroxide biosynthetic process
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative
Research Articles on CYBA
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Products associated with anti-CYBA antibody
Pathways associated with anti-CYBA antibody
Diseases associated with anti-CYBA antibody
Organs/Tissues associated with anti-CYBA antibody
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