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anti-CYCS antibody :: Rabbit CYCS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520232
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYCS, Polyclonal Antibody

★Popular Item★
 Also Known As   

CYCS Polyclonal Antibody

 Product Synonym Names    CYC; HCS; THC4
 Product Gene Name   

anti-CYCS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123970
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    3.1mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CYCS
 Calculated Molecular Weight: 12kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CYCS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYCS antibody

   This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.
 Product Categories/Family for anti-CYCS antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-CYCS antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYCS antibody    WB: 1:500-1:2000
IHC: 1:100-1:300
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 Western Blot (WB) of anti-CYCS antibody    Western Blot analysis of Hela, K562 cell, Mouse brain, heart and kidney tissue, PC3 and Jurkat cell using CYCS Polyclonal Antibody at dilution of 1:700
anti-CYCS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CYCS antibody    Immunohistochemistry of paraffin-embedded Human colon cancer using CYCS Polyclonal Antibody at dilution of 1:70
anti-CYCS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CYCS antibody    Immunohistochemistry of paraffin-embedded Human gastric cancer using CYCS Polyclonal Antibody at dilution of 1:70
anti-CYCS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYCS. It may not necessarily be applicable to this product.
 NCBI GI #    11128019
 NCBI GeneID    54205
 NCBI Accession #    NP_061820.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018947.5 [Other Products]
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 UniProt Secondary Accession #    P00001; Q6NUR2; Q6NX69; Q96BV4; A4D166; B2R4I1 [Other Products]
 UniProt Related Accession #    P99999 [Other Products]
 Molecular Weight    11,749 Da
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 NCBI Official Full Name    cytochrome c
 NCBI Official Synonym Full Names    cytochrome c, somatic
 NCBI Official Symbol    CYCS [Similar Products]
 NCBI Official Synonym Symbols   
CYC; HCS; THC4
[Similar Products]
 NCBI Protein Information    cytochrome c
 UniProt Protein Name    Cytochrome c
 Protein Family    Cytochrome
 UniProt Gene Name    CYCS [Similar Products]
 UniProt Synonym Gene Names    CYC [Similar Products]
 UniProt Entry Name    CYC_HUMAN
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 NCBI Summary for CYCS    This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
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 UniProt Comments for CYCS    CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family.

Protein type: Apoptosis; Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor); Oxidoreductase

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: protein phosphatase type 2A complex; mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; cytosol

Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; protein binding; iron ion binding; heme binding; protein serine/threonine phosphatase activity

Biological Process: cellular metabolic process; mitochondrion organization and biogenesis; response to reactive oxygen species; dephosphorylation; apoptosis; organelle organization and biogenesis; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; DNA fragmentation during apoptosis; caspase activation via cytochrome c; transmembrane transport; mitochondrial electron transport, ubiquinol to cytochrome c

Disease: Thrombocytopenia 4
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 Research Articles on CYCS    1. proposed that mutation of residue 41, and interaction with cardiolipin, increase peroxidase activity by altering the 40-57 Omega loop and its hydrogen bond network with the propionate of haem ring A; these changes enhance access of hydrogen peroxide and substrate to the haem
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYCS antibodyPathways associated with anti-CYCS antibody
 Reference Product  PubMed Publications
 BCL2 antibody  >4 publications with CYCS and BCL2
 APAF1 antibody  >2 publications with CYCS and APAF1
 PPP2CA antibody  >1 publications with CYCS and PPP2CA
 CASP9 antibody  >1 publications with CYCS and CASP9
 CYC1 antibody  >1 publications with CYCS and CYC1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-CYCS antibodyOrgans/Tissues associated with anti-CYCS antibody
 Disease Name  Pubmed Publications
 Thrombocytopenia Antibodies  >6 publications with CYCS and Thrombocytopenia
 Necrosis Antibodies  >2 publications with CYCS and Necrosis
 Neoplasm Metastasis Antibodies  >1 publications with CYCS and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >1 publications with CYCS and Cardiovascular Diseases
 Hypertrophy Antibodies  >1 publications with CYCS and Hypertrophy
 Neoplasms, Experimental Antibodies  >1 publications with CYCS and Neoplasms, Experimental
 Myocardial Infarction Antibodies  >1 publications with CYCS and Myocardial Infarction
 Fibrosis Antibodies  >1 publications with CYCS and Fibrosis
 Heart Diseases Antibodies  >1 publications with CYCS and Heart Diseases
 Thrombocytopenia 4 Antibodies  >1 publications with CYCS and Thrombocytopenia 4
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CYCS and Blood
 Prostate Antibodies  >3 publications with CYCS and Prostate
 Muscle Antibodies  >3 publications with CYCS and Muscle
 Liver Antibodies  >2 publications with CYCS and Liver
 Lung Antibodies  >2 publications with CYCS and Lung
 Vascular Antibodies  >2 publications with CYCS and Vascular
 Heart Antibodies  >2 publications with CYCS and Heart
 Bone Antibodies  >2 publications with CYCS and Bone
 Brain Antibodies  >2 publications with CYCS and Brain
 Intestine Antibodies  >1 publications with CYCS and Intestine
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