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anti-CYP11A1 antibody :: Rabbit CYP11A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128059
Unit / Price
0.05 mL  /  $285 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP11A1, Polyclonal Antibody

 Also Known As   

CYP11A1 Polyclonal Antibody

 Product Synonym Names    CYP11A; CYPXIA1; P450SCC
 Product Gene Name   

anti-CYP11A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613743
 3D Structure    ModBase 3D Structure for P05108
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CYP11A1
 Calculated Molecular Weight    60kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CYP11A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CYP11A1 antibody

   The formation of biologically active steroid hormones is significantly influenced by the motrochondrial cytochrome P450 enzyme, chrolesterol side-chain cleavage. CYP11A1 functions in catalyzing the first step of steroid biosynthesis under modulation of cAMP.It ia also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA. Expression of CYP11A1 has been a useful tool for monitoring the differentiation state of cells from varius endocrine tissues. Identification of CYP11A1 expression by 13363-1-AP detected a ~45kd band in human placenta, with respect to the reported band at 49-52kd by Roby, et al and Durkee, et al.
 Product Categories/Family for anti-CYP11A1 antibody    Polyclonal
 Applications Tested/Suitable for anti-CYP11A1 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CYP11A1 antibody    WB: 1:500 - 1:2000
IF: 1:20 - 1:50
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 Western Blot (WB) of anti-CYP11A1 antibody    Western blot analysis of extracts of various cell lines, using CYP11A1 antibody.
anti-CYP11A1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CYP11A1 antibody    Immunofluorescence analysis of MCF7 cell using CYP11A1 antibody. Blue: DAPI for nuclear staining.
anti-CYP11A1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CYP11A1. It may not necessarily be applicable to this product.
 NCBI GI #    143811381
 NCBI GeneID    1583
 NCBI Accession #    P05108.2 [Other Products]
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 UniProt Primary Accession #    P05108 [Other Products]
 UniProt Secondary Accession #    Q15081; Q16805; Q8N1A7; A8K8D5; B3KPU8; G3XAD7 [Other Products]
 UniProt Related Accession #    P05108 [Other Products]
 Molecular Weight    521
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 NCBI Official Full Name    Cholesterol side-chain cleavage enzyme, mitochondrial
 NCBI Official Synonym Full Names    cytochrome P450, family 11, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP11A1 [Similar Products]
 NCBI Official Synonym Symbols   
CYP11A; CYPXIA1; P450SCC
[Similar Products]
 NCBI Protein Information    cholesterol side-chain cleavage enzyme, mitochondrial; steroid 20-22-lyase; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450C11A1; cholesterol 20-22 desmolase; cholesterol monooxygenase (side-chain cleaving); cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
 UniProt Protein Name    Cholesterol side-chain cleavage enzyme, mitochondrial
 UniProt Synonym Protein Names   
CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
 Protein Family    Cholesterol side-chain cleavage enzyme
 UniProt Gene Name    CYP11A1 [Similar Products]
 UniProt Synonym Gene Names    CYP11A [Similar Products]
 UniProt Entry Name    CP11A_HUMAN
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 NCBI Summary for CYP11A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP11A1    CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family.

Protein type: Mitochondrial; Lipid Metabolism - C21-steroid hormone; Oxidoreductase; EC 1.14.15.6

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: mitochondrial crista; mitochondrion; mitochondrial matrix; perikaryon

Molecular Function: cholesterol monooxygenase (side-chain-cleaving) activity; iron ion binding; cholesterol binding; heme binding

Biological Process: response to alkaloid; steroid metabolic process; maternal process involved in pregnancy; dibenzo-p-dioxin metabolic process; response to insecticide; estrogen biosynthetic process; response to L-ascorbic acid; response to salt stress; response to vitamin E; Leydig cell differentiation; biphenyl metabolic process; response to gamma radiation; cerebellum development; response to corticosterone stimulus; response to drug; cholesterol metabolic process; progesterone biosynthetic process; fractalkine metabolic process; phthalate metabolic process; hippocampus development; mating behavior; vitamin D metabolic process; Schwann cell differentiation; response to genistein; response to hydrogen peroxide; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; sterol metabolic process; granulosa cell differentiation; phenol metabolic process

Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
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 Research Articles on CYP11A1    1. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to CYP11A1 Polyclonal Antibody
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Products associated with anti-CYP11A1 antibodyPathways associated with anti-CYP11A1 antibody
 Reference Product  PubMed Publications
 CYP17A1 antibody  >462 publications with CYP11A1 and CYP17A1
 HSD3B1 antibody  >61 publications with CYP11A1 and HSD3B1
 HSD3B2 antibody  >39 publications with CYP11A1 and HSD3B2
 STS antibody  >5 publications with CYP11A1 and STS
 FDX1 antibody  >5 publications with CYP11A1 and FDX1
 CYP7B1 antibody  >3 publications with CYP11A1 and CYP7B1
 SULT2B1 antibody  >1 publications with CYP11A1 and SULT2B1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
 Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies  Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
 Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies  Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
 Defective CYP1B1 Causes Glaucoma Pathway antibodies  Defective CYP1B1 Causes Glaucoma Pathway Diagram
 Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies  Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
Diseases associated with anti-CYP11A1 antibodyOrgans/Tissues associated with anti-CYP11A1 antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >99 publications with CYP11A1 and Hyperplasia
 Disorders of Sex Development Antibodies  >83 publications with CYP11A1 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >69 publications with CYP11A1 and Genital Diseases, Male
 Adrenal Insufficiency Antibodies  >54 publications with CYP11A1 and Adrenal Insufficiency
 Testicular Diseases Antibodies  >52 publications with CYP11A1 and Testicular Diseases
 Hypertension Antibodies  >29 publications with CYP11A1 and Hypertension
 Necrosis Antibodies  >23 publications with CYP11A1 and Necrosis
 Nervous System Diseases Antibodies  >21 publications with CYP11A1 and Nervous System Diseases
 Infertility, Male Antibodies  >19 publications with CYP11A1 and Infertility, Male
 Cardiovascular Diseases Antibodies  >17 publications with CYP11A1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >733 publications with CYP11A1 and Adrenal Gland
 Ovary Antibodies  >723 publications with CYP11A1 and Ovary
 Testis Antibodies  >445 publications with CYP11A1 and Testis
 Placenta Antibodies  >194 publications with CYP11A1 and Placenta
 Brain Antibodies  >181 publications with CYP11A1 and Brain
 Liver Antibodies  >134 publications with CYP11A1 and Liver
 Embryonic Tissue Antibodies  >91 publications with CYP11A1 and Embryonic Tissue
 Kidney Antibodies  >62 publications with CYP11A1 and Kidney
 Heart Antibodies  >26 publications with CYP11A1 and Heart
 Uterus Antibodies  >23 publications with CYP11A1 and Uterus
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