NP_000488.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,750 Da
NCBI Official Full Name
cytochrome P450 11B1, mitochondrial isoform 1
NCBI Official Synonym Full Names
cytochrome P450 family 11 subfamily B member 1
NCBI Protein Information
cytochrome P450 11B1, mitochondrial
UniProt Protein Name
Cytochrome P450 11B1, mitochondrial
UniProt Synonym Protein Names
CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)
UniProt Synonym Gene Names
NCBI Summary for CYP11B1/2
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP11B1/2
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Research Articles on CYP11B1/2
Precautions
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Disclaimer
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Products associated with anti-CYP11B1/2 antibody
Pathways associated with anti-CYP11B1/2 antibody
Diseases associated with anti-CYP11B1/2 antibody
Organs/Tissues associated with anti-CYP11B1/2 antibody
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