Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CYP11B1 rightarrow Polyclonal CYP11B1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Cysteine-rich with EGF-like domain protein 2-B (creld2-b) Recombinant Protein
 • HINT1 Antibody
 • Apolipoprotein B (APOB) ELISA Kit
 • SLC2A12 cDNA Clone
 • 2-phospho-L-lactate transferase (cofD) Recombinant Protein
 • Suppressor of tumorigenicity 7 protein (ST7) Recombinant Protein
 • Malate Dehydrogenase 1 (MDH1) ELISA Kit
 • NF2 - Merlin Antibody
 • 1,4-alpha-glucan-branching enzyme 2-1, chloroplastic-amylopl... Recombinant Protein
 • SMAD family member 7 (SMAD7) ELISA Kit
 • meningioma expressed antigen 5 (MGEA5) Antibody
 • RAD51 Homolog ELISA Kit
 • Monomethylamine methyltransferase mtmB1 (mtmB1) Recombinant Protein
 • Sphingosine 1 Phosphate (S1P) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CYP11B1 antibody :: Rabbit anti-Human CYP11B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9408369
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP11B1, Polyclonal Antibody

 Also Known As   

CYP11B1 Antibody

 Product Synonym Names    FHI; CPN1; CYP11B; P450C11
 Product Gene Name   

anti-CYP11B1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    103900
 3D Structure    ModBase 3D Structure for P15538
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    The antibody detects endogenous levels of total CYP11B1 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    1.1 mg/ml (lot specific)
Section Bar
 Immunogen Type    Recombinant Protein
 Immunogen Description    Fusion protein corresponding to residues near the C terminal of human cytochrome P450, family 11, subfamily B, polypeptide 1
 Target Name    CYP11B1
Section Bar
 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-CYP11B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-CYP11B1 antibody

   This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
 Product Categories/Family for anti-CYP11B1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-CYP11B1 antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-CYP11B1 antibody    Immunohistochemistry: 1:25-1:100
Section Bar
 Immunohistochemistry (IHC) of anti-CYP11B1 antibody    Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/25.
anti-CYP11B1 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CYP11B1 antibody    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/25.
anti-CYP11B1 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CYP11B1. It may not necessarily be applicable to this product.
 NCBI GI #    61743918
 NCBI GeneID    1584
 NCBI Accession #    NP_000488.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000497.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P15538 [Other Products]
 UniProt Secondary Accession #    Q14095; Q4VAQ8; Q4VAQ9; Q9UML2 [Other Products]
 UniProt Related Accession #    P15538 [Other Products]
 Molecular Weight    49,750 Da
Table BarTOPTable Bar
 NCBI Official Full Name    cytochrome P450 11B1, mitochondrial isoform 1
 NCBI Official Synonym Full Names    cytochrome P450, family 11, subfamily B, polypeptide 1
 NCBI Official Symbol    CYP11B1 [Similar Products]
 NCBI Official Synonym Symbols   
FHI; CPN1; CYP11B; P450C11
[Similar Products]
 NCBI Protein Information    cytochrome P450 11B1, mitochondrial
 UniProt Protein Name    Cytochrome P450 11B1, mitochondrial
 UniProt Synonym Protein Names   
CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)
 Protein Family    Cytochrome
 UniProt Gene Name    CYP11B1 [Similar Products]
 UniProt Synonym Gene Names    S11BH; Cytochrome P450C11 [Similar Products]
 UniProt Entry Name    C11B1_HUMAN
Section Bar
 NCBI Summary for CYP11B1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CYP11B1    CYP11B1: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. Defects in CYP11B1 are the cause of adrenal hyperplasia type 4 (AH4). AH4 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). AH4 patients usually have hypertension. Defects in CYP11B1 are a cause of familial hyperaldosteronism type 1 (FH1). It is a disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension. The molecular defect causing hyperaldosteronism familial type 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Lipid Metabolism - androgen and estrogen; Mitochondrial; EC 1.14.15.4

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: mitochondrion; mitochondrial inner membrane

Molecular Function: steroid 11-beta-monooxygenase activity; iron ion binding; heme binding

Biological Process: steroid metabolic process; regulation of blood pressure; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; immune response; glucose homeostasis; glucocorticoid biosynthetic process; aldosterone biosynthetic process; sterol metabolic process; cellular response to hormone stimulus

Disease: Adrenal Hyperplasia, Congenital, Due To Steroid 11-beta-hydroxylase Deficiency; Glucocorticoid-remediable Aldosteronism
Table BarTOPTable Bar
 Research Articles on CYP11B1    1. Mutations in the CYP11B1 gene are the cause of 11beta-hydroxylase deficiency.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CYP11B1 antibodyPathways associated with anti-CYP11B1 antibody
 Reference Product  PubMed Publications
 CYP11B2 antibody  >473 publications with CYP11B1 and CYP11B2
 POMC antibody  >206 publications with CYP11B1 and POMC
 CYP17A1 antibody  >185 publications with CYP11B1 and CYP17A1
 HSD3B2 antibody  >23 publications with CYP11B1 and HSD3B2
 HSD17B2 antibody  >10 publications with CYP11B1 and HSD17B2
 HSD11B2 antibody  >9 publications with CYP11B1 and HSD11B2
 HSD3B1 antibody  >6 publications with CYP11B1 and HSD3B1
 HSD17B3 antibody  >5 publications with CYP11B1 and HSD17B3
 HSD11B1 antibody  >4 publications with CYP11B1 and HSD11B1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-CYP11B1 antibodyOrgans/Tissues associated with anti-CYP11B1 antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >292 publications with CYP11B1 and Hyperplasia
 Hypertension Antibodies  >265 publications with CYP11B1 and Hypertension
 Urogenital Abnormalities Antibodies  >228 publications with CYP11B1 and Urogenital Abnormalities
 Hyperaldosteronism Antibodies  >139 publications with CYP11B1 and Hyperaldosteronism
 Cushing Syndrome Antibodies  >41 publications with CYP11B1 and Cushing Syndrome
 Glucocorticoid-Remediable Aldosteronism Antibodies  >41 publications with CYP11B1 and Glucocorticoid-Remediable Aldosteronism
 Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency Antibodies  >31 publications with CYP11B1 and Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency
 Genital Diseases, Male Antibodies  >22 publications with CYP11B1 and Genital Diseases, Male
 Hypertrophy Antibodies  >22 publications with CYP11B1 and Hypertrophy
 Puberty, Precocious Antibodies  >21 publications with CYP11B1 and Puberty, Precocious
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >612 publications with CYP11B1 and Adrenal Gland
 Brain Antibodies  >85 publications with CYP11B1 and Brain
 Kidney Antibodies  >39 publications with CYP11B1 and Kidney
 Muscle Antibodies  >32 publications with CYP11B1 and Muscle
 Placenta Antibodies  >15 publications with CYP11B1 and Placenta
 Mammary Gland Antibodies  >1 publications with CYP11B1 and Mammary Gland
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions