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anti-CYP17A1 antibody :: Goat CYP17A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421228
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP17A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-CYP17A1 Antibody

 Product Synonym Names    CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; HGNC: 2593; CPT7; CYP17; P450C17; S17AH; cytochrome P450, family 17; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; cytochrome p450 XVIIA1; steroid 17-a; CYP17A1 antibody; cytochrome P450; family 17; subfamily A; polypeptide 1 antibody; HGNC: 2593 antibody; CPT7 antibody; CYP17 antibody; P450C17 antibody; S17AH antibody; cytochrome P450; family 17 antibody; cytochrome P450; subfamily XVII (steroid 17-alpha-hydroxylase); adrenal hyperplasia antibody; cytochrome p450 XVIIA1 antibody; steroid 17-alpha-hydroxylase/17; 20 lyase antibody; steroid 17-alpha-monooxygenase antibody
 Product Gene Name   

anti-CYP17A1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CYP17A1 peptide (MBS425548) is used for blocking the activity of CYP17A1 antibody (MBS421228)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    LFKDGDQKLE K
 OMIM    202110
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Cat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-LFKDGDQKLEK, from the internal region of the protein sequence according to NP_000093.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP17A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP17A1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYP17A1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Adenal Gland shows strong granular staining of the cytoplasm in medulla cells. Recommended concentration, 3-5ug/ml.
Western Blot: Approx 60kDa band observed in human ovary lysates (calculated MW of 57.4kDa according to NP_000093.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-CYP17A1 antibody    (0.3ug/ml) staining of human ovary lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CYP17A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CYP17A1 antibody    (3.8ug/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-CYP17A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP17A1. It may not necessarily be applicable to this product.
 NCBI GI #    4503195
 NCBI GeneID    1586
 NCBI Accession #    NP_000093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000102.3 [Other Products]
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 UniProt Secondary Accession #    Q5TZV7 [Other Products]
 UniProt Related Accession #    P05093 [Other Products]
 Molecular Weight    57,371 Da
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 NCBI Official Full Name    steroid 17-alpha-hydroxylase/17,20 lyase
 NCBI Official Synonym Full Names    cytochrome P450 family 17 subfamily A member 1
 NCBI Official Symbol    CYP17A1 [Similar Products]
 NCBI Official Synonym Symbols   
CPT7; CYP17; S17AH; P450C17
[Similar Products]
 NCBI Protein Information    steroid 17-alpha-hydroxylase/17,20 lyase
 UniProt Protein Name    Steroid 17-alpha-hydroxylase/17,20 lyase
 UniProt Synonym Protein Names   
17-alpha-hydroxyprogesterone aldolase (EC:4.1.2.30
 Protein Family    Steroid 17-alpha-hydroxylase/17,20 lyase
 UniProt Gene Name    CYP17A1 [Similar Products]
 UniProt Synonym Gene Names    CYP17; S17AH; Cytochrome P450c17 [Similar Products]
 UniProt Entry Name    CP17A_HUMAN
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 NCBI Summary for CYP17A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP17A1    CYP17A1: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; EC 4.1.2.30; EC 1.14.99.9; Lipid Metabolism - C21-steroid hormone

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: axon; cell soma; endoplasmic reticulum; endoplasmic reticulum membrane; mitochondrion

Molecular Function: 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; oxygen binding; steroid 17-alpha-monooxygenase activity

Biological Process: adrenal gland development; androgen biosynthetic process; biphenyl metabolic process; dibenzo-p-dioxin metabolic process; glucocorticoid biosynthetic process; hippocampus development; hormone biosynthetic process; Leydig cell differentiation; ovulation; phenol metabolic process; phthalate metabolic process; progesterone metabolic process; response to acetate; response to cAMP; response to cytokine stimulus; response to drug; response to herbicide; response to insecticide; response to ionizing radiation; response to methylmercury; response to nutrient levels; response to retinoic acid; response to steroid hormone stimulus; sex differentiation; steroid biosynthetic process; steroid metabolic process; sterol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 17-alpha-hydroxylase Deficiency
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 Research Articles on CYP17A1    1. Thus, CYP17A1 may contribute to cardiac hypertrophy in this clinical condition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP17A1 antibodyPathways associated with anti-CYP17A1 antibody
 Reference Product  PubMed Publications
 CYP19A1 antibody  >519 publications with CYP17A1 and CYP19A1
 POMC antibody  >205 publications with CYP17A1 and POMC
 HSD17B2 antibody  >109 publications with CYP17A1 and HSD17B2
 HSD3B1 antibody  >68 publications with CYP17A1 and HSD3B1
 HSD3B2 antibody  >57 publications with CYP17A1 and HSD3B2
 HSD17B3 antibody  >35 publications with CYP17A1 and HSD17B3
 ESR1 antibody  >34 publications with CYP17A1 and ESR1
 SRD5A1 antibody  >27 publications with CYP17A1 and SRD5A1
 GATA4 antibody  >11 publications with CYP17A1 and GATA4
 HSD17B6 antibody  >4 publications with CYP17A1 and HSD17B6
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
Diseases associated with anti-CYP17A1 antibodyOrgans/Tissues associated with anti-CYP17A1 antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >352 publications with CYP17A1 and Hyperplasia
 Genital Diseases, Male Antibodies  >343 publications with CYP17A1 and Genital Diseases, Male
 Adrenal Hyperplasia, Congenital Antibodies  >294 publications with CYP17A1 and Adrenal Hyperplasia, Congenital
 Prostatic Neoplasms Antibodies  >284 publications with CYP17A1 and Prostatic Neoplasms
 Hypertension Antibodies  >207 publications with CYP17A1 and Hypertension
 Breast Neoplasms Antibodies  >119 publications with CYP17A1 and Breast Neoplasms
 Ovarian Cysts Antibodies  >117 publications with CYP17A1 and Ovarian Cysts
 Cardiovascular Diseases Antibodies  >112 publications with CYP17A1 and Cardiovascular Diseases
 Amenorrhea Antibodies  >68 publications with CYP17A1 and Amenorrhea
 Hypogonadism Antibodies  >52 publications with CYP17A1 and Hypogonadism
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >641 publications with CYP17A1 and Testis
 Ovary Antibodies  >571 publications with CYP17A1 and Ovary
 Adrenal Gland Antibodies  >567 publications with CYP17A1 and Adrenal Gland
 Brain Antibodies  >129 publications with CYP17A1 and Brain
 Kidney Antibodies  >69 publications with CYP17A1 and Kidney
 Embryonic Tissue Antibodies  >63 publications with CYP17A1 and Embryonic Tissue
 Muscle Antibodies  >27 publications with CYP17A1 and Muscle
 Thyroid Antibodies  >15 publications with CYP17A1 and Thyroid
 Mammary Gland Antibodies  >3 publications with CYP17A1 and Mammary Gland
 Bladder Antibodies  >3 publications with CYP17A1 and Bladder
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