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anti-CYP1A1 antibody :: Rabbit CYP1A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127670
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP1A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CYP1A1 Polyclonal Antibody

 Product Synonym Names    AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
 Product Gene Name   

anti-CYP1A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    108330
 3D Structure    ModBase 3D Structure for P04798
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Species    Human
 Immunogen    Recombinant Protein of human CYP1A1
 Category    Primary Antibodies
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CYP1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYP1A1 antibody

   This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-CYP1A1 antibody    Polyclonal
 Applications Tested/Suitable for anti-CYP1A1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYP1A1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-CYP1A1 antibody    Western blot analysis of extracts of various cell lines, using CYP1A1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-CYP1A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CYP1A1 antibody    Immunohistochemistry of paraffin-embedded rat testis using CYP1A1 antibody at dilution of 1:200 (40x lens).
anti-CYP1A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CYP1A1 antibody    Immunohistochemistry of paraffin-embedded human esophageal cancer using CYP1A1 antibody at dilution of 1:200 (40x lens).
anti-CYP1A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CYP1A1 antibody    Immunohistochemistry of paraffin-embedded human lung cancer using CYP1A1 antibody at dilution of 1:100 (40x lens).
anti-CYP1A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CYP1A1 antibody    Immunohistochemistry of paraffin-embedded human colon carcinoma using CYP1A1 antibody at dilution of 1:100 (40x lens).
anti-CYP1A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP1A1. It may not necessarily be applicable to this product.
 NCBI GI #    117139
 NCBI GeneID    1543
 NCBI Accession #    P04798.1 [Other Products]
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 UniProt Primary Accession #    P04798 [Other Products]
 UniProt Secondary Accession #    Q53G18; A4F3V9; A4F3W0 [Other Products]
 UniProt Related Accession #    P04798 [Other Products]
 Molecular Weight    58kDa
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 NCBI Official Full Name    Cytochrome P450 1A1
 NCBI Official Synonym Full Names    cytochrome P450, family 1, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP1A1 [Similar Products]
 NCBI Official Synonym Symbols   
AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
[Similar Products]
 NCBI Protein Information    cytochrome P450 1A1; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
 UniProt Protein Name    Cytochrome P450 1A1
 UniProt Synonym Protein Names   
CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1
 Protein Family    Cytochrome
 UniProt Gene Name    CYP1A1 [Similar Products]
 UniProt Entry Name    CP1A1_HUMAN
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 NCBI Summary for CYP1A1    This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP1A1    CYP1A1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.

Protein type: Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: endoplasmic reticulum membrane; mitochondrion

Molecular Function: oxidoreductase activity, acting on diphenols and related substances as donors; flavonoid 3'-monooxygenase activity; enzyme binding; iron ion binding; heme binding; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; demethylase activity

Biological Process: coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; arachidonic acid metabolic process; drug metabolic process; aging; response to food; response to drug; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; epoxygenase P450 pathway; response to herbicide; dibenzo-p-dioxin catabolic process; vitamin D metabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; response to hypoxia; 9-cis-retinoic acid biosynthetic process; amine metabolic process; hydrogen peroxide biosynthetic process
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 Research Articles on CYP1A1    1. the data suggest a putative downregulation of CYP1A1 and CYP1B1 expression in endometrial tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP1A1 antibodyPathways associated with anti-CYP1A1 antibody
 Reference Product  PubMed Publications
 AHR antibody  >1386 publications with CYP1A1 and AHR
 GSTM1 antibody  >636 publications with CYP1A1 and GSTM1
 GSTP1 antibody  >278 publications with CYP1A1 and GSTP1
 EPHX1 antibody  >184 publications with CYP1A1 and EPHX1
 UGT1A1 antibody  >69 publications with CYP1A1 and UGT1A1
 GSTA1 antibody  >32 publications with CYP1A1 and GSTA1
 GSTA2 antibody  >15 publications with CYP1A1 and GSTA2
 GSTA3 antibody  >6 publications with CYP1A1 and GSTA3
 GSTA4 antibody  >4 publications with CYP1A1 and GSTA4
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
Diseases associated with anti-CYP1A1 antibodyOrgans/Tissues associated with anti-CYP1A1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >556 publications with CYP1A1 and Liver Diseases
 Liver Neoplasms Antibodies  >492 publications with CYP1A1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >366 publications with CYP1A1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >357 publications with CYP1A1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >278 publications with CYP1A1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >225 publications with CYP1A1 and Carcinoma, Hepatocellular
 Liver Neoplasms, Experimental Antibodies  >203 publications with CYP1A1 and Liver Neoplasms, Experimental
 Inflammation Antibodies  >186 publications with CYP1A1 and Inflammation
 Necrosis Antibodies  >146 publications with CYP1A1 and Necrosis
 Cardiovascular Diseases Antibodies  >144 publications with CYP1A1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3793 publications with CYP1A1 and Liver
 Blood Antibodies  >1113 publications with CYP1A1 and Blood
 Lung Antibodies  >880 publications with CYP1A1 and Lung
 Brain Antibodies  >281 publications with CYP1A1 and Brain
 Intestine Antibodies  >242 publications with CYP1A1 and Intestine
 Skin Antibodies  >221 publications with CYP1A1 and Skin
 Heart Antibodies  >163 publications with CYP1A1 and Heart
 Embryonic Tissue Antibodies  >128 publications with CYP1A1 and Embryonic Tissue
 Prostate Antibodies  >100 publications with CYP1A1 and Prostate
 Uterus Antibodies  >85 publications with CYP1A1 and Uterus
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