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anti-CYP1A2 antibody :: Rabbit anti-Human CYP1A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9405122
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP1A2, Polyclonal Antibody

 Also Known As   

CYP1A2 Antibody

 Product Synonym Names    CP12; P3-450; P450(PA)
 Product Gene Name   

anti-CYP1A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    108330
 3D Structure    ModBase 3D Structure for P05177
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous levels of total CYP1A2 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    2.2 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to a region derived from internal residues of human cytochrome P450, family 1, subfamily A, polypeptide 2
 Target Name    CYP1A2
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-CYP1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYP1A2 antibody

   This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
 Product Categories/Family for anti-CYP1A2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-CYP1A2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYP1A2 antibody    Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
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 Testing Data of anti-CYP1A2 antibody    Gel: 6%SDS-PAGE Lysate: 40ug Human hepatocellular carcinoma tissue
anti-CYP1A2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CYP1A2 antibody    Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/40.
anti-CYP1A2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP1A2. It may not necessarily be applicable to this product.
 NCBI GI #    73915100
 NCBI GeneID    1544
 NCBI Accession #    NP_000752.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000761.4 [Other Products]
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 UniProt Primary Accession #    P05177 [Other Products]
 UniProt Secondary Accession #    Q16754; Q6NWU5; Q9BXX7; Q9UK49 [Other Products]
 UniProt Related Accession #    P05177 [Other Products]
 Molecular Weight    58,407 Da
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 NCBI Official Full Name    cytochrome P450 1A2
 NCBI Official Synonym Full Names    cytochrome P450, family 1, subfamily A, polypeptide 2
 NCBI Official Symbol    CYP1A2 [Similar Products]
 NCBI Official Synonym Symbols   
CP12; P3-450; P450(PA)
[Similar Products]
 NCBI Protein Information    cytochrome P450 1A2
 UniProt Protein Name    Cytochrome P450 1A2
 UniProt Synonym Protein Names   
CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
 Protein Family    Cytochrome
 UniProt Gene Name    CYP1A2 [Similar Products]
 UniProt Entry Name    CP1A2_HUMAN
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 NCBI Summary for CYP1A2    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP1A2    CYP1A2: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.14.1; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - linoleic acid; Amino Acid Metabolism - tryptophan; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Secondary Metabolites Metabolism - caffeine

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: enzyme binding; electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxidoreductase activity; monooxygenase activity; demethylase activity

Biological Process: methylation; dibenzo-p-dioxin metabolic process; cellular respiration; monoterpenoid metabolic process; toxin biosynthetic process; response to lipopolysaccharide; epoxygenase P450 pathway; monocarboxylic acid metabolic process; response to estradiol stimulus; post-embryonic development; drug catabolic process; regulation of gene expression; xenobiotic metabolic process; porphyrin metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process; alkaloid metabolic process; heterocycle metabolic process; drug metabolic process; hydrogen peroxide biosynthetic process; steroid catabolic process; lung development
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 Research Articles on CYP1A2    1. Age-dependent CYP1A2 gene polymorphism -163C>A in three ethnic groups of Bashkortostan Republic residents.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP1A2 antibodyPathways associated with anti-CYP1A2 antibody
 Reference Product  PubMed Publications
 UGT1A1 antibody  >84 publications with CYP1A2 and UGT1A1
 GSTM1 antibody  >72 publications with CYP1A2 and GSTM1
 GSTP1 antibody  >63 publications with CYP1A2 and GSTP1
 UGT1A6 antibody  >44 publications with CYP1A2 and UGT1A6
 GSTT1 antibody  >42 publications with CYP1A2 and GSTT1
 UGT1A9 antibody  >28 publications with CYP1A2 and UGT1A9
 UGT1A7 antibody  >14 publications with CYP1A2 and UGT1A7
 UGT1A10 antibody  >7 publications with CYP1A2 and UGT1A10
 NR1I3 antibody  >3 publications with CYP1A2 and NR1I3
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Aromatic Amines Can Be N-hydroxylated Or N-dealkylated By CYP1A2 Pathway antibodies  Aromatic Amines Can Be N-hydroxylated Or N-dealkylated By CYP1A2 Pathway Diagram
 Arylamine Metabolism Pathway antibodies  Arylamine Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
Diseases associated with anti-CYP1A2 antibodyOrgans/Tissues associated with anti-CYP1A2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >369 publications with CYP1A2 and Liver Diseases
 Liver Neoplasms Antibodies  >196 publications with CYP1A2 and Liver Neoplasms
 Nervous System Diseases Antibodies  >108 publications with CYP1A2 and Nervous System Diseases
 Drug-Induced Liver Injury Antibodies  >100 publications with CYP1A2 and Drug-Induced Liver Injury
 Inflammation Antibodies  >97 publications with CYP1A2 and Inflammation
 Poisoning Antibodies  >93 publications with CYP1A2 and Poisoning
 Drug-Related Side Effects and Adverse Reactions Antibodies  >89 publications with CYP1A2 and Drug-Related Side Effects and Adverse Reactions
 Carcinoma, Hepatocellular Antibodies  >83 publications with CYP1A2 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >78 publications with CYP1A2 and Cardiovascular Diseases
 Liver Neoplasms, Experimental Antibodies  >76 publications with CYP1A2 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2974 publications with CYP1A2 and Liver
 Mammary Gland Antibodies  >21 publications with CYP1A2 and Mammary Gland
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