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anti-CYP24A1 antibody :: Rabbit CYP24A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS768383 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.1 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP24A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CYP24A1 Rabbit Polyclonal

 Product Gene Name   

anti-CYP24A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126065
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Purity: >=95% as determined by SDS-PAGE
Purificaton: Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    Cytochrome P450, family 24, subfamily A, polypeptide 1
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
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 Preparation and Storage    Store at -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP24A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP24A1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-CYP24A1 antibody    WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
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 Immunohistochemistry of anti-CYP24A1 antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS768383 (CYP24A1 antibody) at dilution of 1:50
anti-CYP24A1 antibody Immunohistochemistry (IHC) image
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 Western Blot of anti-CYP24A1 antibody    HeLa cells were subjected to SDS PAGE followed by western blot with MBS768383 (CYP24A1 antibody) at dilution of 1:300
anti-CYP24A1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for CYP24A1. It may not necessarily be applicable to this product.
 NCBI GI #    80478115
 NCBI GeneID    1591
 NCBI Accession #    AAI09085.1 [Other Products]
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 UniProt Secondary Accession #    Q15807; Q32ML3; Q5I2W7 [Other Products]
 UniProt Related Accession #    Q07973 [Other Products]
 Molecular Weight    59kDa
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 NCBI Official Full Name    CYP24A1 protein
 NCBI Official Synonym Full Names    cytochrome P450 family 24 subfamily A member 1
 NCBI Official Symbol    CYP24A1 [Similar Products]
 NCBI Official Synonym Symbols   
CP24; HCAI; CYP24; HCINF1; P450-CC24
[Similar Products]
 NCBI Protein Information    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
 UniProt Protein Name    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
 UniProt Synonym Protein Names   
Cytochrome P450 24A1; Cytochrome P450-CC24
 Protein Family    1,25-dihydroxyvitamin D(3) 24-hydroxylase
 UniProt Gene Name    CYP24A1 [Similar Products]
 UniProt Synonym Gene Names    CYP24; 24-OHase; Vitamin D(3) 24-hydroxylase [Similar Products]
 UniProt Entry Name    CP24A_HUMAN
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 NCBI Summary for CYP24A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP24A1    CYP24A1: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.13.126; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane

Molecular Function: 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; oxidoreductase activity

Biological Process: osteoblast differentiation; response to vitamin D; vitamin D catabolic process; vitamin D metabolic process; vitamin metabolic process

Disease: Hypercalcemia, Infantile
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 Research Articles on CYP24A1    1. Results indicate that rs964293 modifies the association between estrogen and progestogen postmenopausal hormone replacement therapy and colorectal cancer risk. [Meta-Analysis]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP24A1 antibodyPathways associated with anti-CYP24A1 antibody
 Reference Product  PubMed Publications
 VDR antibody  >494 publications with CYP24A1 and VDR
 CYP27B1 antibody  >471 publications with CYP24A1 and CYP27B1
 PTH antibody  >83 publications with CYP24A1 and PTH
 AHR antibody  >1 publications with CYP24A1 and AHR
 NR1I2 antibody  >1 publications with CYP24A1 and NR1I2
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
Diseases associated with anti-CYP24A1 antibodyOrgans/Tissues associated with anti-CYP24A1 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >109 publications with CYP24A1 and Kidney Diseases
 Hypercalcemia Antibodies  >85 publications with CYP24A1 and Hypercalcemia
 Prostatic Neoplasms Antibodies  >66 publications with CYP24A1 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >61 publications with CYP24A1 and Breast Neoplasms
 Inflammation Antibodies  >37 publications with CYP24A1 and Inflammation
 Disease Models, Animal Antibodies  >35 publications with CYP24A1 and Disease Models, Animal
 Renal Insufficiency Antibodies  >33 publications with CYP24A1 and Renal Insufficiency
 Osteoporosis Antibodies  >29 publications with CYP24A1 and Osteoporosis
 Hypercalciuria Antibodies  >29 publications with CYP24A1 and Hypercalciuria
 Nervous System Diseases Antibodies  >24 publications with CYP24A1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >382 publications with CYP24A1 and Kidney
 Blood Antibodies  >300 publications with CYP24A1 and Blood
 Intestine Antibodies  >126 publications with CYP24A1 and Intestine
 Skin Antibodies  >96 publications with CYP24A1 and Skin
 Liver Antibodies  >88 publications with CYP24A1 and Liver
 Prostate Antibodies  >86 publications with CYP24A1 and Prostate
 Brain Antibodies  >25 publications with CYP24A1 and Brain
 Embryonic Tissue Antibodies  >25 publications with CYP24A1 and Embryonic Tissue
 Mammary Gland Antibodies  >8 publications with CYP24A1 and Mammary Gland
 Cervix Antibodies  >4 publications with CYP24A1 and Cervix
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