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anti-CYP2C19 antibody :: Rabbit anti-Human CYP2C19 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2539121
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP2C19, Polyclonal Antibody

★Popular Item★
 Also Known As   

CYP2C19 Polyclonal Antibody

 Product Synonym Names    CYP2C19; Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
 Product Gene Name   

anti-CYP2C19 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    124020
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human CYP2C19.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23436 / sc-23435
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP2C19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CYP2C19 antibody    Epigenetics
 Applications Tested/Suitable for anti-CYP2C19 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CYP2C19 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-CYP2C19 antibody    Western Blot analysis of Mouse brain using CYP2C19 Polyclonal Antibody at dilution of 1:1000.
anti-CYP2C19 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CYP2C19. It may not necessarily be applicable to this product.
 NCBI GI #    4503219
 NCBI GeneID    1557
 NCBI Accession #    NP_000760.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000769.2 [Other Products]
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 UniProt Secondary Accession #    P33259; Q8WZB1; Q8WZB2; Q9UCD4 [Other Products]
 UniProt Related Accession #    P33261 [Other Products]
 Molecular Weight    Calculated MW: 56
Observed MW: 56
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 NCBI Official Full Name    cytochrome P450 2C19
 NCBI Official Synonym Full Names    cytochrome P450 family 2 subfamily C member 19
 NCBI Official Symbol    CYP2C19 [Similar Products]
 NCBI Official Synonym Symbols   
CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
[Similar Products]
 NCBI Protein Information    cytochrome P450 2C19
 UniProt Protein Name    Cytochrome P450 2C19
 UniProt Synonym Protein Names   
(R)-limonene 6-monooxygenase (EC:1.14.13.80); (S)-limonene 6-monooxygenase (EC:1.14.13.48); (S)-limonene 7-monooxygenase (EC:1.14.13.49); CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2C19 [Similar Products]
 UniProt Entry Name    CP2CJ_HUMAN
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 NCBI Summary for CYP2C19    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP2C19    CYP2C19: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.13.49; Oxidoreductase; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.80; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - arachidonic acid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 1.14.13.48

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: (S)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; arachidonic acid epoxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity

Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process

Disease: Drug Metabolism, Poor, Cyp2c19-related
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 Research Articles on CYP2C19    1. Genetic variation in the CYP2C19 gene in a healthy Mexican population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP2C19 antibodyPathways associated with anti-CYP2C19 antibody
 Reference Product  PubMed Publications
 CYP3A4 antibody  >1374 publications with CYP2C19 and CYP3A4
 CYP3A5 antibody  >724 publications with CYP2C19 and CYP3A5
 GSTM1 antibody  >28 publications with CYP2C19 and GSTM1
 CYP4F2 antibody  >24 publications with CYP2C19 and CYP4F2
 GSTT1 antibody  >24 publications with CYP2C19 and GSTT1
 GSTP1 antibody  >21 publications with CYP2C19 and GSTP1
 CYP4A11 antibody  >16 publications with CYP2C19 and CYP4A11
 GSTA1 antibody  >8 publications with CYP2C19 and GSTA1
 PTGS2 antibody  >7 publications with CYP2C19 and PTGS2
 CYP4F3 antibody  >4 publications with CYP2C19 and CYP4F3
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
Diseases associated with anti-CYP2C19 antibodyOrgans/Tissues associated with anti-CYP2C19 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >472 publications with CYP2C19 and Cardiovascular Diseases
 Gastrointestinal Diseases Antibodies  >203 publications with CYP2C19 and Gastrointestinal Diseases
 Thrombosis Antibodies  >177 publications with CYP2C19 and Thrombosis
 Nervous System Diseases Antibodies  >176 publications with CYP2C19 and Nervous System Diseases
 Mental Disorders Antibodies  >144 publications with CYP2C19 and Mental Disorders
 Liver Diseases Antibodies  >108 publications with CYP2C19 and Liver Diseases
 Depressive Disorder Antibodies  >61 publications with CYP2C19 and Depressive Disorder
 Drug-Related Side Effects and Adverse Reactions Antibodies  >61 publications with CYP2C19 and Drug-Related Side Effects and Adverse Reactions
 Pain Antibodies  >50 publications with CYP2C19 and Pain
 Hypertension Antibodies  >32 publications with CYP2C19 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1140 publications with CYP2C19 and Liver
 Mixed Antibodies  >1031 publications with CYP2C19 and Mixed
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