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anti-CYP3A4 antibody :: Rabbit CYP3A4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128082
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP3A4, Polyclonal Antibody

 Also Known As   

CYP3A4 Polyclonal Antibody

 Product Synonym Names    CP33; CP34; CYP3A; CYP3A3; HLP; MGC126680; NF-25; P450C3; P450PCN1
 Product Gene Name   

anti-CYP3A4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    124010
 3D Structure    ModBase 3D Structure for P08684
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CYP3A4
 Calculated Molecular Weight    57kD
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CYP3A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CYP3A4 antibody

   Cytochrome P450 3A (CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in a tissue-specific manner(PMID:17975676).This antibody is specific to CYP3A4.
 Product Categories/Family for anti-CYP3A4 antibody    Polyclonal
 Applications Tested/Suitable for anti-CYP3A4 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CYP3A4 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:20 - 1:100
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 Western Blot (WB) of anti-CYP3A4 antibody    Western blot analysis of extracts of Mouse liver, using CYP3A4 antibody.
anti-CYP3A4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CYP3A4. It may not necessarily be applicable to this product.
 NCBI GI #    116241312
 NCBI GeneID    1576
 NCBI Accession #    P08684.4 [Other Products]
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 UniProt Primary Accession #    P08684 [Other Products]
 UniProt Secondary Accession #    P05184; Q16757; Q9UK50 [Other Products]
 UniProt Related Accession #    P08684 [Other Products]
 Molecular Weight    503
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 NCBI Official Full Name    Cytochrome P450 3A4
 NCBI Official Synonym Full Names    cytochrome P450, family 3, subfamily A, polypeptide 4
 NCBI Official Symbol    CYP3A4 [Similar Products]
 NCBI Official Synonym Symbols   
HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
[Similar Products]
 NCBI Protein Information    cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; 1,8-cineole 2-exo-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
 UniProt Protein Name    Cytochrome P450 3A4
 UniProt Synonym Protein Names   
1,8-cineole 2-exo-monooxygenase (EC:1.14.13.157); Albendazole monooxygenase (EC:1.14.13.32); Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase (EC:1.14.13.67); Taurochenodeoxycholate 6-alpha-hydroxylase (EC:1.14.13.97)
 Protein Family    Cytochrome
 UniProt Gene Name    CYP3A4 [Similar Products]
 UniProt Synonym Gene Names    CYP3A3 [Similar Products]
 UniProt Entry Name    CP3A4_HUMAN
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 NCBI Summary for CYP3A4    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
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 UniProt Comments for CYP3A4    CYP3A4: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cell surface; Oxidoreductase; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - linoleic acid; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane

Molecular Function: quinine 3-monooxygenase activity; albendazole monooxygenase activity; taurochenodeoxycholate 6alpha-hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxidoreductase activity; oxygen binding; vitamin D3 25-hydroxylase activity; testosterone 6-beta-hydroxylase activity; steroid binding; enzyme binding; iron ion binding; heme binding; steroid hydroxylase activity; monooxygenase activity

Biological Process: steroid metabolic process; drug catabolic process; xenobiotic metabolic process; androgen metabolic process; exogenous drug catabolic process; monoterpenoid metabolic process; alkaloid catabolic process; heterocycle metabolic process; lipid metabolic process; drug metabolic process; vitamin D metabolic process; steroid catabolic process
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 Research Articles on CYP3A4    1. Results show significant CYP3A4 overexpression in breast cancer in comparison with healthy tissue. CYP3A4 expression was associated with smoking, alcohol consumption and hormonal contraceptive use as well as estrogen and progesterone receptor positivity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP3A4 antibodyPathways associated with anti-CYP3A4 antibody
 Reference Product  PubMed Publications
 UGT1A1 antibody  >138 publications with CYP3A4 and UGT1A1
 UGT2B7 antibody  >63 publications with CYP3A4 and UGT2B7
 UGT1A9 antibody  >39 publications with CYP3A4 and UGT1A9
 UGT1A4 antibody  >19 publications with CYP3A4 and UGT1A4
 GSTA1 antibody  >16 publications with CYP3A4 and GSTA1
 UGT1A7 antibody  >9 publications with CYP3A4 and UGT1A7
 UGT1A8 antibody  >8 publications with CYP3A4 and UGT1A8
 GSTA2 antibody  >7 publications with CYP3A4 and GSTA2
 UGT1A10 antibody  >4 publications with CYP3A4 and UGT1A10
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
Diseases associated with anti-CYP3A4 antibodyOrgans/Tissues associated with anti-CYP3A4 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >535 publications with CYP3A4 and Liver Diseases
 Cardiovascular Diseases Antibodies  >360 publications with CYP3A4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >332 publications with CYP3A4 and Nervous System Diseases
 Heart Diseases Antibodies  >191 publications with CYP3A4 and Heart Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >190 publications with CYP3A4 and Drug-Related Side Effects and Adverse Reactions
 Pain Antibodies  >186 publications with CYP3A4 and Pain
 Kidney Diseases Antibodies  >180 publications with CYP3A4 and Kidney Diseases
 Hypertension Antibodies  >166 publications with CYP3A4 and Hypertension
 Breast Neoplasms Antibodies  >157 publications with CYP3A4 and Breast Neoplasms
 Inflammation Antibodies  >141 publications with CYP3A4 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5068 publications with CYP3A4 and Liver
 Intestine Antibodies  >821 publications with CYP3A4 and Intestine
 Kidney Antibodies  >717 publications with CYP3A4 and Kidney
 Brain Antibodies  >234 publications with CYP3A4 and Brain
 Muscle Antibodies  >122 publications with CYP3A4 and Muscle
 Stomach Antibodies  >45 publications with CYP3A4 and Stomach
 Mouth Antibodies  >33 publications with CYP3A4 and Mouth
 Adrenal Gland Antibodies  >24 publications with CYP3A4 and Adrenal Gland
 Connective Tissue Antibodies  >23 publications with CYP3A4 and Connective Tissue
 Mammary Gland Antibodies  >7 publications with CYP3A4 and Mammary Gland
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