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anti-CYP3A4 antibody :: Goat CYP3A4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420553 anti-CYP3A4 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP3A4, Polyclonal Antibody

 Also Known As   

Goat anti-CYP3A4 Antibody

 Product Synonym Names    CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HGNC: 2637; CP33; CP34; CYP3A; CYP3A3; HLP; NF-25; P450C3; P450PCN1; P450-III, steroid inducible; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfami; CYP3A4 antibody; cytochrome P450; family 3; subfamily A; polypeptide 4 antibody; HGNC: 2637 antibody; CP33 antibody; CP34 antibody; CYP3A antibody; CYP3A3 antibody; HLP antibody; NF-25 antibody; P450C3 antibody; P450PCN1 antibody; P450-III; steroid inducible antibody; cytochrome P450; subfamily IIIA (niphedipine oxidase); polypeptide 3 antibody; cytochrome P450; subfamily IIIA (niphedipine oxidase); polypeptide 4 antibody; cytochrome P450; subfamily IIIA; polypeptide 4 antibody; glucocorticoid-inducible P450 antibody; nifedipine oxidase antibody
 Product Gene Name   

anti-CYP3A4 antibody

[Similar Products]
 Antibody/Peptide Pairs    CYP3A4 peptide (MBS426504) is used for blocking the activity of CYP3A4 antibody (MBS420553)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KESRLEDTQK HR
 OMIM    124010
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KESRLEDTQKHR, from the internal region of the protein sequence according to NP_059488.2; NP_001189784.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_059488.2; NP_001189784.1) and it is not expected to cross-react with 3A5, 3A7 ot 3A43.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP3A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP3A4 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-CYP3A4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx 26-27kDa band in human liver lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 57.3kDa according to NP_059488.2. The 26-27kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for CYP3A4. It may not necessarily be applicable to this product.
 NCBI GI #    13435386
 NCBI GeneID    1576
 NCBI Accession #    NP_059488.2 [Other Products]
 NCBI Related Accession #    NP_001189784.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017460.5 [Other Products]
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 UniProt Secondary Accession #    P05184; Q16757; Q9UK50 [Other Products]
 UniProt Related Accession #    P08684 [Other Products]
 Molecular Weight    57,343 Da
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 NCBI Official Full Name    cytochrome P450 3A4 isoform 1
 NCBI Official Synonym Full Names    cytochrome P450 family 3 subfamily A member 4
 NCBI Official Symbol    CYP3A4 [Similar Products]
 NCBI Official Synonym Symbols   
HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
[Similar Products]
 NCBI Protein Information    cytochrome P450 3A4
 UniProt Protein Name    Cytochrome P450 3A4
 UniProt Synonym Protein Names   
1,8-cineole 2-exo-monooxygenase (EC:1.14.13.157); Albendazole monooxygenase (EC:1.14.13.32); Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase
 Protein Family    Cytochrome
 UniProt Gene Name    CYP3A4 [Similar Products]
 UniProt Synonym Gene Names    CYP3A3 [Similar Products]
 UniProt Entry Name    CP3A4_HUMAN
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 NCBI Summary for CYP3A4    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
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 UniProt Comments for CYP3A4    CYP3A4: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - linoleic acid; Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: cytoplasm; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle

Molecular Function: albendazole monooxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; quinine 3-monooxygenase activity; steroid binding; steroid hydroxylase activity; taurochenodeoxycholate 6alpha-hydroxylase activity; testosterone 6-beta-hydroxylase activity; vitamin D3 25-hydroxylase activity

Biological Process: alkaloid catabolic process; androgen metabolic process; drug catabolic process; drug metabolic process; exogenous drug catabolic process; heterocycle metabolic process; lipid metabolic process; monoterpenoid metabolic process; steroid catabolic process; steroid metabolic process; vitamin D metabolic process; xenobiotic metabolic process
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 Research Articles on CYP3A4    1. The Fg values for CYP3A4 substrates for which intravenous data were not available.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP3A4 antibodyPathways associated with anti-CYP3A4 antibody
 Reference Product  PubMed Publications
 UGT1A1 antibody  >171 publications with CYP3A4 and UGT1A1
 UGT2B7 antibody  >84 publications with CYP3A4 and UGT2B7
 NR1I2 antibody  >82 publications with CYP3A4 and NR1I2
 UGT1A9 antibody  >51 publications with CYP3A4 and UGT1A9
 FMO1 antibody  >48 publications with CYP3A4 and FMO1
 UGT1A6 antibody  >41 publications with CYP3A4 and UGT1A6
 NR1I3 antibody  >37 publications with CYP3A4 and NR1I3
 UGT1A4 antibody  >26 publications with CYP3A4 and UGT1A4
 UGT1A3 antibody  >22 publications with CYP3A4 and UGT1A3
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
Diseases associated with anti-CYP3A4 antibodyOrgans/Tissues associated with anti-CYP3A4 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >632 publications with CYP3A4 and Liver Diseases
 Nervous System Diseases Antibodies  >386 publications with CYP3A4 and Nervous System Diseases
 Liver Neoplasms Antibodies  >271 publications with CYP3A4 and Liver Neoplasms
 Drug-Related Side Effects and Adverse Reactions Antibodies  >216 publications with CYP3A4 and Drug-Related Side Effects and Adverse Reactions
 Heart Diseases Antibodies  >209 publications with CYP3A4 and Heart Diseases
 Kidney Diseases Antibodies  >199 publications with CYP3A4 and Kidney Diseases
 Pain Antibodies  >189 publications with CYP3A4 and Pain
 Hypertension Antibodies  >189 publications with CYP3A4 and Hypertension
 Breast Neoplasms Antibodies  >170 publications with CYP3A4 and Breast Neoplasms
 Drug-Induced Liver Injury Antibodies  >167 publications with CYP3A4 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5511 publications with CYP3A4 and Liver
 Intestine Antibodies  >874 publications with CYP3A4 and Intestine
 Kidney Antibodies  >800 publications with CYP3A4 and Kidney
 Brain Antibodies  >267 publications with CYP3A4 and Brain
 Muscle Antibodies  >131 publications with CYP3A4 and Muscle
 Stomach Antibodies  >47 publications with CYP3A4 and Stomach
 Mouth Antibodies  >37 publications with CYP3A4 and Mouth
 Adrenal Gland Antibodies  >29 publications with CYP3A4 and Adrenal Gland
 Connective Tissue Antibodies  >27 publications with CYP3A4 and Connective Tissue
 Mammary Gland Antibodies  >8 publications with CYP3A4 and Mammary Gland
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