NP_000887.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
NCBI Official Synonym Full Names
cytochrome P450, family 4, subfamily F, polypeptide 3
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase
UniProt Synonym Gene Names
UniProt Entry Name
CP4F3_HUMAN
NCBI Summary for CYP4F3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP4F3
CYP4F3: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. Belongs to the cytochrome P450 family.
Protein type: Membrane protein, integral; EC 1.14.13.30; Oxidoreductase; Lipid Metabolism - arachidonic acid
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; monooxygenase activity
Biological Process: xenobiotic metabolic process; icosanoid metabolic process; arachidonic acid metabolic process; leukotriene metabolic process
Product References and Citations for anti-CYP4F3 antibody
Kikuta,Y., et.al., FEBS Lett. 348 (1), 70-74 (1994) Kikuta,Y., et,al., DNA Cell Biol. 17 (3), 221-230 (1998)
Research Articles on CYP4F3
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Products associated with anti-CYP4F3 antibody
Diseases associated with anti-CYP4F3 antibody
Organs/Tissues associated with anti-CYP4F3 antibody
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