AAH18429.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 56kDa
NCBI Official Full Name
CYP51A1 protein, partial
NCBI Official Synonym Full Names
cytochrome P450 family 51 subfamily A member 1
NCBI Official Synonym Symbols
LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM [Similar Products]
NCBI Protein Information
lanosterol 14-alpha demethylase
UniProt Protein Name
Lanosterol 14-alpha demethylase
UniProt Synonym Protein Names
CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
UniProt Synonym Gene Names
UniProt Entry Name
CP51A_HUMAN
NCBI Summary for CYP51A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for CYP51A1
CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.13.70; Membrane protein, integral; Lipid Metabolism - steroid biosynthesis; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; plasma membrane
Molecular Function: heme binding; iron ion binding; sterol 14-demethylase activity
Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol; steroid biosynthetic process; sterol metabolic process; xenobiotic metabolic process
Research Articles on CYP51A1
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Products associated with anti-CYP51A1 antibody
Pathways associated with anti-CYP51A1 antibody
Diseases associated with anti-CYP51A1 antibody
Organs/Tissues associated with anti-CYP51A1 antibody
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