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anti-CYP7B1 antibody :: Goat CYP7B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420441
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP7B1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-CYP7B1 Antibody

 Product Synonym Names    CYP7B1; CP7B; cytochrome P450, family 7, subfamily B, polypeptide 1; oxysterol 7alpha-hydroxylase; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; CBAS3; SPG5A; CYP7B1 antibody; CP7B antibody; cytochrome P450; family 7; subfamily B; polypeptide 1 antibody; oxysterol 7alpha-hydroxylase antibody; cytochrome P450; subfamily VIIB (oxysterol 7 alpha-hydroxylase); polypeptide 1 antibody; CBAS3 antibody; SPG5A antibody
 Product Gene Name   

anti-CYP7B1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CYP7B1 peptide (MBS425932) is used for blocking the activity of CYP7B1 antibody (MBS420441)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    YPDSDVLFRY KVKS
 OMIM    270800
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-YPDSDVLFRYKVKS, from the C Terminus of the protein sequence according to NP_004811.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP7B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP7B1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-CYP7B1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Breast shows textured cytoplasm staining in ductal epithelial cells. Recommended concentration, 3-6ug/ml.
Western Blot: Preliminary experiments in Human Liver, Kidney and Prostate lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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 Immunohistochemistry (IHC) of anti-CYP7B1 antibody    (4ug/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
anti-CYP7B1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP7B1. It may not necessarily be applicable to this product.
 NCBI GI #    4758104
 NCBI GeneID    9420
 NCBI Accession #    NP_004811.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004820.3 [Other Products]
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 UniProt Secondary Accession #    Q9UNF5; B2RN07 [Other Products]
 UniProt Related Accession #    O75881 [Other Products]
 Molecular Weight    58,256 Da
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 NCBI Official Full Name    25-hydroxycholesterol 7-alpha-hydroxylase
 NCBI Official Synonym Full Names    cytochrome P450 family 7 subfamily B member 1
 NCBI Official Symbol    CYP7B1 [Similar Products]
 NCBI Official Synonym Symbols   
CP7B; CBAS3; SPG5A
[Similar Products]
 NCBI Protein Information    25-hydroxycholesterol 7-alpha-hydroxylase
 UniProt Protein Name    25-hydroxycholesterol 7-alpha-hydroxylase
 UniProt Synonym Protein Names   
Cytochrome P450 7B1; Oxysterol 7-alpha-hydroxylase
 Protein Family    25-hydroxycholesterol 7-alpha-hydroxylase
 UniProt Gene Name    CYP7B1 [Similar Products]
 UniProt Entry Name    CP7B1_HUMAN
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 NCBI Summary for CYP7B1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]
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 UniProt Comments for CYP7B1    CYP7B1: Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3). Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable. Belongs to the cytochrome P450 family.

Protein type: Endoplasmic reticulum; Lipid Metabolism - primary bile acid biosynthesis; EC 1.14.13.100; Oxidoreductase

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 25-hydroxycholesterol 7alpha-hydroxylase activity; heme binding; iron ion binding; oxysterol 7-alpha-hydroxylase activity

Biological Process: bile acid biosynthetic process; cholesterol metabolic process; negative regulation of estrogen receptor signaling pathway; positive regulation of epithelial cell proliferation; sterol metabolic process

Disease: Bile Acid Synthesis Defect, Congenital, 3; Spastic Paraplegia 5a, Autosomal Recessive
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 Research Articles on CYP7B1    1. Spastic paraplegia type 5 has a higher frequency in Taiwanese than in other ethnic groups, associated with a CYP7B1 founder mutation and its phenotype is characterized by pronounced dorsal column sensory loss, with cerebellar ataxia in some patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP7B1 antibodyPathways associated with anti-CYP7B1 antibody
 Reference Product  PubMed Publications
 CYP27A1 antibody  >32 publications with CYP7B1 and CYP27A1
 CH25H antibody  >4 publications with CYP7B1 and CH25H
 CYP11A1 antibody  >3 publications with CYP7B1 and CYP11A1
 SQLE antibody  >2 publications with CYP7B1 and SQLE
 HSD3B2 antibody  >2 publications with CYP7B1 and HSD3B2
 HSD3B7 antibody  >2 publications with CYP7B1 and HSD3B7
 CYP17A1 antibody  >1 publications with CYP7B1 and CYP17A1
 SULT2B1 antibody  >1 publications with CYP7B1 and SULT2B1
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
Diseases associated with anti-CYP7B1 antibodyOrgans/Tissues associated with anti-CYP7B1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >24 publications with CYP7B1 and Liver Diseases
 Spastic Paraplegia, Hereditary Antibodies  >23 publications with CYP7B1 and Spastic Paraplegia, Hereditary
 Inflammation Antibodies  >15 publications with CYP7B1 and Inflammation
 Cholestasis Antibodies  >13 publications with CYP7B1 and Cholestasis
 Fatty Liver Antibodies  >11 publications with CYP7B1 and Fatty Liver
 Necrosis Antibodies  >7 publications with CYP7B1 and Necrosis
 Disease Models, Animal Antibodies  >7 publications with CYP7B1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >6 publications with CYP7B1 and Liver Neoplasms
 Drug-Induced Liver Injury Antibodies  >5 publications with CYP7B1 and Drug-Induced Liver Injury
 Liver Cirrhosis Antibodies  >5 publications with CYP7B1 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >46 publications with CYP7B1 and Brain
 Kidney Antibodies  >18 publications with CYP7B1 and Kidney
 Prostate Antibodies  >9 publications with CYP7B1 and Prostate
 Lung Antibodies  >4 publications with CYP7B1 and Lung
 Muscle Antibodies  >4 publications with CYP7B1 and Muscle
 Embryonic Tissue Antibodies  >3 publications with CYP7B1 and Embryonic Tissue
 Eye Antibodies  >1 publications with CYP7B1 and Eye
 Connective Tissue Antibodies  >1 publications with CYP7B1 and Connective Tissue
 Mammary Gland Antibodies  >1 publications with CYP7B1 and Mammary Gland
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