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anti-CYSLT2 antibody :: Rabbit CYSLT2 / CYSLTR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240917
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYSLT2 / CYSLTR2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CYSLT2 / CYSLTR2

 Product Synonym Names    Anti-CYSLT2 / CYSLTR2 Antibody (Extracellular Domain) IHC-plus; CYSLTR2; CysLT(2); CYSLT2; CYSLT2R; CysLT-2; HG57; HGPCR21; KPG_011; PSEC0146; HPN321; Human CYSLT2; CYSLTR2
 Product Gene Name   

anti-CYSLT2 antibody

[Similar Products]
 Product Synonym Gene Name    CYSLTR2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605666
 3D Structure    ModBase 3D Structure for Q9NS75
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Horse, Human
Predicted Reactivity: Gorilla, Monkey, Mouse (at least 90% immunogen sequence identity)
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 Specificity    Human CYSLTR2 / CYSLT2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR109B (59%), OXGR1 (59%), GPR81 (59%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from 1st extracellular domain of human CYSLTR2 / CYSLT2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset, Horse (100%); Gorilla, Monkey, Mouse, Panda (94%)
 Immunogen Type    Synthetic peptide
 Immunogen    CYSLT2 / CYSLTR2 antibody was raised against synthetic 17 amino acid peptide from 1st extracellular domain of human CYSLTR2 / CYSLT2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset, Horse (100%); Gorilla, Monkey, Mouse, Panda (94%); Dog, Bovine, Hamster, Elephant, Rabbit, Opossum (88%); Pig (82%).
 Antigen Modification    Extracellular Domain
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-CYSLT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYSLT2 antibody

   Cysteinyl leukotriene receptor 2 (CysLT2) is a Chemoattractant Receptor that binds neutrophil chemoattractants such as cysteinyl leukotrienes. These ligands have potent proinflammatory activity and are implicated in many features of asthma including edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Activation of cysteinyl leukotriene receptor 2 induces cell contraction and/or relaxation.
 Product Categories/Family for anti-CYSLT2 antibody    Family: GPCR
Subfamily: Chemoattractant
 Applications Tested/Suitable for anti-CYSLT2 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-CYSLT2 antibody    ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CYSLT2 antibody    Anti-CYSLTR2 / CYSLT2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-CYSLT2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYSLT2. It may not necessarily be applicable to this product.
 NCBI GI #    9966851
 NCBI GeneID    57105
 NCBI Accession #    NP_065110.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020377.2 [Other Products]
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 UniProt Primary Accession #    Q9NS75 [Other Products]
 UniProt Secondary Accession #    Q9HCQ2 [Other Products]
 UniProt Related Accession #    Q9NS75 [Other Products]
 Molecular Weight    39,635 Da
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 NCBI Official Full Name    cysteinyl leukotriene receptor 2
 NCBI Official Synonym Full Names    cysteinyl leukotriene receptor 2
 NCBI Official Symbol    CYSLTR2 [Similar Products]
 NCBI Official Synonym Symbols   
HG57; CYSLT2; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
[Similar Products]
 NCBI Protein Information    cysteinyl leukotriene receptor 2; G protein-coupled receptor; G-protein coupled receptor HG57; G-protein coupled receptor GPCR21; cysteinyl leukotriene CysLT2 receptor
 UniProt Protein Name    Cysteinyl leukotriene receptor 2
 UniProt Synonym Protein Names   
G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321
 UniProt Gene Name    CYSLTR2 [Similar Products]
 UniProt Synonym Gene Names    CYSLT2; CYSLT2R; CysLTR2; hGPCR21 [Similar Products]
 UniProt Entry Name    CLTR2_HUMAN
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 NCBI Summary for CYSLT2    The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYSLT2    CYSLTR2: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; cysteinyl leukotriene receptor activity; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; immune response
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 Research Articles on CYSLT2    1. Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYSLT2 antibodyPathways associated with anti-CYSLT2 antibody
 Reference Product  PubMed Publications
 CYSLTR1 antibody  >15 publications with CYSLT2 and CYSLTR1
 TBXA2R antibody  >3 publications with CYSLT2 and TBXA2R
 LTB4R antibody  >1 publications with CYSLT2 and LTB4R
 GPR17 antibody  >1 publications with CYSLT2 and GPR17
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CYSLT2 antibodyOrgans/Tissues associated with anti-CYSLT2 antibody
 Disease Name  Pubmed Publications
 Asthma Antibodies  >18 publications with CYSLT2 and Asthma
 Lung Diseases, Obstructive Antibodies  >15 publications with CYSLT2 and Lung Diseases, Obstructive
 Inflammation Antibodies  >7 publications with CYSLT2 and Inflammation
 Rhinitis Antibodies  >4 publications with CYSLT2 and Rhinitis
 Drug Hypersensitivity Antibodies  >3 publications with CYSLT2 and Drug Hypersensitivity
 Asthma, Aspirin-Induced Antibodies  >3 publications with CYSLT2 and Asthma, Aspirin-Induced
 Eosinophilia Antibodies  >2 publications with CYSLT2 and Eosinophilia
 Urticaria Antibodies  >2 publications with CYSLT2 and Urticaria
 Pain Antibodies  >1 publications with CYSLT2 and Pain
 Cardiovascular Diseases Antibodies  >1 publications with CYSLT2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with CYSLT2 and Placenta
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