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anti-CAMK2A antibody :: Rabbit CaMK2 alpha/delta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8218549
Unit / Price
0.03 mL  /  $165 +1 FREE 8GB USB
0.1 mL  /  $245 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CaMK2 alpha/delta (CAMK2A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-CaMK2 alpha/delta (pT286) Antibody

 Product Synonym Names    CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta
 Product Gene Name   

anti-CAMK2A antibody

[Similar Products]
 Product Synonym Gene Name    CAMK2D [Similar Products]
 Antibody/Peptide Pairs    CaMK2 alpha/delta peptide (MBS8204720) is used for blocking the activity of CaMK2 alpha/delta antibody (MBS8218549)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114078
 3D Structure    ModBase 3D Structure for Q9UQM7
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Chicken, Monkey, Porcine, Rabbit
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 Specificity    Recognizes endogenous levels of CaMK2 alpha/delta (pT286) protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CaMK2 alpha/delta. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CAMK2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CAMK2A antibody

   Rabbit polyclonal antibody to CaMK2 alpha/delta (pT286)
 Applications Tested/Suitable for anti-CAMK2A antibody   

Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-CAMK2A antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF (1/100 - 1/500), ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-CAMK2A antibody    Western blot analysis of CaMK2 alpha/delta (pT286) expression in HeLa (A) whole cell lysates.
anti-CAMK2A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CAMK2A antibody    Immunohistochemical analysis of CaMK2 alpha/delta (pT286) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w
anti-CAMK2A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CAMK2A antibody    Immunofluorescent analysis of CaMK2 alpha/delta (pT286) staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-CAMK2A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CAMK2A. It may not necessarily be applicable to this product.
 NCBI GI #    25952118
 NCBI GeneID    815
 NCBI Accession #    NP_741960.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_171825.2 [Other Products]
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 UniProt Primary Accession #    Q9UQM7 [Other Products]
 UniProt Secondary Accession #    Q9UL21; Q9Y2H4; Q9Y352 [Other Products]
 UniProt Related Accession #    Q9UQM7 [Other Products]
 Molecular Weight    55,320 Da
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 NCBI Official Full Name    calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
 NCBI Official Synonym Full Names    calcium/calmodulin-dependent protein kinase II alpha
 NCBI Official Symbol    CAMK2A [Similar Products]
 NCBI Official Synonym Symbols   
CAMKA
[Similar Products]
 NCBI Protein Information    calcium/calmodulin-dependent protein kinase type II subunit alpha
 UniProt Protein Name    Calcium/calmodulin-dependent protein kinase type II subunit alpha
 Protein Family    Calcium/calmodulin-dependent protein kinase
 UniProt Gene Name    CAMK2A [Similar Products]
 UniProt Synonym Gene Names    CAMKA; KIAA0968; CaM kinase II subunit alpha; CaMK-II subunit alpha [Similar Products]
 UniProt Entry Name    KCC2A_HUMAN
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 NCBI Summary for CAMK2A    The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
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 UniProt Comments for CAMK2A    CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.17; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: nucleoplasm; presynaptic membrane; mitochondrion; plasma membrane; cytosol; nucleus; cell junction

Molecular Function: calmodulin binding; protein serine/threonine kinase activity; protein binding; glutamate receptor binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; kinase activity; ATP binding

Biological Process: synaptic transmission; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; calcium ion transport; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle; regulation of neuronal synaptic plasticity; activation of NF-kappaB transcription factor
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 Research Articles on CAMK2A    1. we describe for the first time, two patients with MFD and ID and for whom a deletion encompassing TCOF1 and CAMK2A has been identified
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CAMK2A antibodyPathways associated with anti-CAMK2A antibody
 Reference Product  PubMed Publications
 CREB1 antibody  >2 publications with CAMK2A and CREB1
 NOS1 antibody  >2 publications with CAMK2A and NOS1
 GRIN2A antibody  >2 publications with CAMK2A and GRIN2A
 MAPT antibody  >2 publications with CAMK2A and MAPT
 GRIN2B antibody  >2 publications with CAMK2A and GRIN2B
 GRIN1 antibody  >1 publications with CAMK2A and GRIN1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Diseases associated with anti-CAMK2A antibodyOrgans/Tissues associated with anti-CAMK2A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >52 publications with CAMK2A and Nervous System Diseases
 Brain Diseases Antibodies  >36 publications with CAMK2A and Brain Diseases
 Pain Antibodies  >8 publications with CAMK2A and Pain
 Seizures Antibodies  >8 publications with CAMK2A and Seizures
 Memory Disorders Antibodies  >6 publications with CAMK2A and Memory Disorders
 Movement Disorders Antibodies  >6 publications with CAMK2A and Movement Disorders
 Learning Disorders Antibodies  >5 publications with CAMK2A and Learning Disorders
 Inflammation Antibodies  >5 publications with CAMK2A and Inflammation
 Cognition Disorders Antibodies  >4 publications with CAMK2A and Cognition Disorders
 Anxiety Disorders Antibodies  >4 publications with CAMK2A and Anxiety Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >150 publications with CAMK2A and Brain
 Muscle Antibodies  >6 publications with CAMK2A and Muscle
 Eye Antibodies  >4 publications with CAMK2A and Eye
 Embryonic Tissue Antibodies  >4 publications with CAMK2A and Embryonic Tissue
 Kidney Antibodies  >4 publications with CAMK2A and Kidney
 Heart Antibodies  >3 publications with CAMK2A and Heart
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