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anti-CaMKIIdelta antibody :: Rabbit CaMKIIdelta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2537731
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CaMKIIdelta, Polyclonal Antibody

★Popular Item★
 Also Known As   

CaMKIIdelta Polyclonal Antibody

 Product Synonym Names    CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta
 Product Gene Name   

anti-CaMKIIdelta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607708
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human CaMKIIdelta.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CaMKIIdelta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CaMKIIdelta antibody    Neuroscience
 Applications Tested/Suitable for anti-CaMKIIdelta antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CaMKIIdelta antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-CaMKIIdelta antibody    Western Blot analysis of K562 cells with CaMKII? Polyclonal Antibody.
anti-CaMKIIdelta antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CaMKIIdelta antibody    Immunohistochemistry of paraffin-embedded Mouse brain tissue using CaMKII? Polyclonal Antibody at dilution of 1:100.
anti-CaMKIIdelta antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CaMKIIdelta. It may not necessarily be applicable to this product.
 NCBI GI #    212549756
 NCBI GeneID    817
 NCBI Accession #    NP_742127.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_172129.1 [Other Products]
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 UniProt Secondary Accession #    Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9; A8MVS8 [Other Products]
 UniProt Related Accession #    Q13557 [Other Products]
 Molecular Weight    Calculated MW: 56
Observed MW: 56
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 NCBI Official Full Name    calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4
 NCBI Official Synonym Full Names    calcium/calmodulin-dependent protein kinase II delta
 NCBI Official Symbol    CAMK2D [Similar Products]
 NCBI Official Synonym Symbols   
CAMKD
[Similar Products]
 NCBI Protein Information    calcium/calmodulin-dependent protein kinase type II subunit delta
 UniProt Protein Name    Calcium/calmodulin-dependent protein kinase type II subunit delta
 UniProt Gene Name    CAMK2D [Similar Products]
 UniProt Synonym Gene Names    CAMKD; CaM kinase II subunit delta; CaMK-II subunit delta [Similar Products]
 UniProt Entry Name    KCC2D_HUMAN
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 NCBI Summary for CaMKIIdelta    The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
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 UniProt Comments for CaMKIIdelta    Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
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 Research Articles on CaMKIIdelta    1. This study showed that AKAP12,CAMK2D and a molecular pathway(cyclic amp)association to outcome of depressive during citalopram treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CaMKIIdelta antibodyPathways associated with anti-CaMKIIdelta antibody
 Reference Product  PubMed Publications
 CAMK2G antibody  >7 publications with CaMKIIdelta and CAMK2G
 RYR2 antibody  >4 publications with CaMKIIdelta and RYR2
 CAMK2B antibody  >3 publications with CaMKIIdelta and CAMK2B
 CALM2 antibody  >1 publications with CaMKIIdelta and CALM2
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
Diseases associated with anti-CaMKIIdelta antibodyOrgans/Tissues associated with anti-CaMKIIdelta antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >20 publications with CaMKIIdelta and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with CaMKIIdelta and Disease Models, Animal
 Arrhythmias, Cardiac Antibodies  >6 publications with CaMKIIdelta and Arrhythmias, Cardiac
 Nervous System Diseases Antibodies  >3 publications with CaMKIIdelta and Nervous System Diseases
 Seizures Antibodies  >2 publications with CaMKIIdelta and Seizures
 Brain Diseases Antibodies  >2 publications with CaMKIIdelta and Brain Diseases
 Myocardial Ischemia Antibodies  >2 publications with CaMKIIdelta and Myocardial Ischemia
 Abnormalities, Drug-Induced Antibodies  >1 publications with CaMKIIdelta and Abnormalities, Drug-Induced
 Lung Neoplasms Antibodies  >1 publications with CaMKIIdelta and Lung Neoplasms
 Depressive Disorder Antibodies  >1 publications with CaMKIIdelta and Depressive Disorder
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >32 publications with CaMKIIdelta and Muscle
 Heart Antibodies  >29 publications with CaMKIIdelta and Heart
 Brain Antibodies  >11 publications with CaMKIIdelta and Brain
 Blood Antibodies  >7 publications with CaMKIIdelta and Blood
 Embryonic Tissue Antibodies  >4 publications with CaMKIIdelta and Embryonic Tissue
 Pancreas Antibodies  >4 publications with CaMKIIdelta and Pancreas
 Lung Antibodies  >3 publications with CaMKIIdelta and Lung
 Kidney Antibodies  >2 publications with CaMKIIdelta and Kidney
 Connective Tissue Antibodies  >2 publications with CaMKIIdelta and Connective Tissue
 Ear Antibodies  >1 publications with CaMKIIdelta and Ear
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