ABD04093.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
121,773 Da
NCBI Official Full Name
calcium sensing receptor, partial
NCBI Official Synonym Full Names
calcium sensing receptor
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1 [Similar Products]
NCBI Protein Information
extracellular calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor 1
UniProt Synonym Gene Names
NCBI Summary for CASR
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
UniProt Comments for CASR
CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q13.33-q21.1
Cellular Component: apical plasma membrane; axon; axon terminus; basolateral plasma membrane; cell soma; cell surface; cytoplasm; integral component of plasma membrane; nucleus; plasma membrane
Molecular Function: amino acid binding; calcium ion binding; drug binding; G-protein coupled receptor activity; integrin binding; ion channel binding; magnesium ion binding; phosphoinositide phospholipase C activity; polyamine binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process: anatomical structure morphogenesis; apoptosis; branching morphogenesis of a tube; cellular calcium ion homeostasis; cellular response to glucose stimulus; cellular response to hypoxia; cellular response to low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to vitamin D; chemosensory behavior; detection of calcium ion; G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; JNK cascade; ossification; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of ATPase activity; positive regulation of calcium ion import; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of insulin secretion; positive regulation of positive chemotaxis; positive regulation of vasoconstriction; response to fibroblast growth factor; vasodilation
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
Research Articles on CASR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CASR antibody
Pathways associated with anti-CASR antibody
Diseases associated with anti-CASR antibody
Organs/Tissues associated with anti-CASR antibody
|