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anti-CASR antibody :: Rabbit anti-Human Calcium Sensing Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9404827
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcium Sensing Receptor (CASR), Polyclonal Antibody

 Also Known As   

Calcium Sensing Receptor (Phospho-Thr888) Antibody

 Product Synonym Names    CAR, FHH, FIH, HHC, EIG8
 Product Gene Name   

anti-CASR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    145980
 3D Structure    ModBase 3D Structure for P41180
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous level of Calcium Sensing Receptor only when phosphorylated at Threonine 888.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of Threonine 888
 Modification    Phospho-Thr888
 Target Name    Calcium Sensing Receptor
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-CASR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CASR antibody

   Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
 Product Categories/Family for anti-CASR antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-CASR antibody   

Western Blot (WB)

 Application Notes for anti-CASR antibody    Western blotting: 1:500~1:1000
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 Western Blot (WB) of anti-CASR antibody    Western blot analysis of extracts from LOVO cells using Calcium Sensing Receptor (Phospho-Thr888) Antibody.The lane on the left is treated with the antigen-specific peptide.
anti-CASR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
 NCBI GI #    37577159
 NCBI GeneID    846
 NCBI Accession #    NP_000379.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000388.3 [Other Products]
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 UniProt Primary Accession #    P41180 [Other Products]
 UniProt Secondary Accession #    Q13912; Q16108; Q16109; Q16110; Q16379; Q2M1T0; Q4PJ19 [Other Products]
 UniProt Related Accession #    P41180 [Other Products]
 Molecular Weight    121,772 Da [Similar Products]
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 NCBI Official Full Name    extracellular calcium-sensing receptor isoform 2
 NCBI Official Synonym Full Names    calcium-sensing receptor
 NCBI Official Symbol    CASR [Similar Products]
 NCBI Official Synonym Symbols   
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
[Similar Products]
 NCBI Protein Information    extracellular calcium-sensing receptor
 UniProt Protein Name    Extracellular calcium-sensing receptor
 UniProt Synonym Protein Names   
Parathyroid cell calcium-sensing receptor 1; PCaR1
 Protein Family    Calcium sensing receptor
 UniProt Gene Name    CASR [Similar Products]
 UniProt Synonym Gene Names    GPRC2A; PCAR1; CaSR; PCaR1 [Similar Products]
 UniProt Entry Name    CASR_HUMAN
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 NCBI Summary for CASR    The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASR    CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, integral; GPCR, family 3

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; ossification; metabolic process; chemosensory behavior; detection of calcium ion

Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1
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 Research Articles on CASR    1. The intron 4 polymorphism in CASR is a factor in diabetic nephropathy and diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CASR antibodyPathways associated with anti-CASR antibody
 Reference Product  PubMed Publications
 PTH antibody  >252 publications with CASR and PTH
 SST antibody  >2 publications with CASR and SST
 APP antibody  >2 publications with CASR and APP
 AGT antibody  >1 publications with CASR and AGT
 AVP antibody  >1 publications with CASR and AVP
 NPSR1 antibody  >1 publications with CASR and NPSR1
 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 E-cadherin Signaling In Keratinocytes Pathway antibodies  E-cadherin Signaling In Keratinocytes Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-CASR antibodyOrgans/Tissues associated with anti-CASR antibody
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >247 publications with CASR and Hyperparathyroidism
 Hypercalcemia Antibodies  >211 publications with CASR and Hypercalcemia
 Hypocalcemia Antibodies  >129 publications with CASR and Hypocalcemia
 Kidney Diseases Antibodies  >102 publications with CASR and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >86 publications with CASR and Hyperparathyroidism, Secondary
 Hypoparathyroidism Antibodies  >82 publications with CASR and Hypoparathyroidism
 Hypertension Antibodies  >48 publications with CASR and Hypertension
 Hypocalciuric hypercalcemia, familial, type 1 Antibodies  >29 publications with CASR and Hypocalciuric hypercalcemia, familial, type 1
 Inflammation Antibodies  >26 publications with CASR and Inflammation
 Renal Insufficiency Antibodies  >25 publications with CASR and Renal Insufficiency
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >415 publications with CASR and Parathyroid
 Kidney Antibodies  >256 publications with CASR and Kidney
 Liver Antibodies  >34 publications with CASR and Liver
 Pancreas Antibodies  >21 publications with CASR and Pancreas
 Eye Antibodies  >1 publications with CASR and Eye
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