NP_149129.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
caldesmon isoform 1
NCBI Official Synonym Full Names
caldesmon 1
NCBI Official Synonym Symbols
CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22; MGC21352 [Similar Products]
NCBI Protein Information
caldesmon; OTTHUMP00000207948; OTTHUMP00000207949; OTTHUMP00000207950; OTTHUMP00000207952; OTTHUMP00000207953; OTTHUMP00000207954; OTTHUMP00000207955; OTTHUMP00000214473
UniProt Protein Name
Caldesmon
UniProt Synonym Gene Names
UniProt Entry Name
CALD1_HUMAN
NCBI Summary for CALD1
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
UniProt Comments for CALD1
Caldesmon: a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: cytoskeleton; myofibril; plasma membrane; cytosol; actin cap; actin cytoskeleton
Molecular Function: calmodulin binding; myosin binding; actin binding; tropomyosin binding
Biological Process: muscle contraction; cell motility
Research Articles on CALD1
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Pathways associated with anti-CALD1 antibody
Diseases associated with anti-CALD1 antibody
Organs/Tissues associated with anti-CALD1 antibody
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