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anti-CANX antibody :: Rabbit Calnexin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617024 anti-CANX antibody
Unit / Price
0.05 mL  /  $410 +1 FREE 8GB USB
0.2 mL  /  $565 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calnexin (CANX), Polyclonal Antibody

 Also Known As   

Calnexin

 Product Synonym Names    Anti -Calnexin
 Product Gene Name   

anti-CANX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (179125930..179158642). Location: 5q35
 OMIM    114217
 3D Structure    ModBase 3D Structure for P27824
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine, Canine, Chicken, Drosophila, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Xenopus
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 Specificity    Recognizes canine Calnexin. MW
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
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 Immunogen    Synthetic peptide corresponding to the C-terminus of canine calnexin. The sequence is completely conserved in human, mouse and rat.
 Positive Control    Heat Shocked HeLa Cell Lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CANX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CANX antibody

   Calnexin (CNX), an abundant ~90kD molecular chaperone, is an unglycosylated resident ER transmembrane protein. In mammalian cells, calnexin, together with calreticulin (CRT), plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglucosylated glycans (4). Calnexin associates with newly synthesized monomeric glycoproteins and only recognizes glycoproteins when they are incompletely folded. Calnexin associates with numerous oligomeric protein complexes within the ER, including beta1 and alpha6 integrins (5), major histocompatibility class I (6, 7) and class II molecules (11), the antigen receptors expressed on T and B lymphocytes (7), human thyroperoxidase (hTPO) (12), and acetylcholine receptor (13). Recent data also suggest that calnexin might be responsible for the prolonged retention of pro-alpha6 integrin within ER compartment (14). Furthermore, calnexin has been demonstrated to function as a bonafide molecular chaperone capable of interacting with polypeptide segments of folding glycoproteins (15).
 Product Categories/Family for anti-CANX antibody    Antibodies; Abs to Calnexin
 Applications Tested/Suitable for anti-CANX antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-CANX antibody    Suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry and Electron microscopy.
Dilution: Western Blot: 1:1000 (Colorimetric)
Immunohistochemistry: Paraffin sections
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NCBI/Uniprot data below describe general gene information for CANX. It may not necessarily be applicable to this product.
 NCBI GI #    186523
 NCBI GeneID    821
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 UniProt Primary Accession #    P27824 [Other Products]
 UniProt Secondary Accession #    B2R5V8; D3DWQ3 [Other Products]
 UniProt Related Accession #    P27824; Q6ZP56 [Other Products]
 Molecular Weight    67,568 Da [Similar Products]
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 NCBI Official Full Name    calnexin
 NCBI Official Synonym Full Names    calnexin
 NCBI Official Symbol    CANX [Similar Products]
 NCBI Official Synonym Symbols   
CNX; P90; IP90; FLJ26570
[Similar Products]
 NCBI Protein Information    calnexin; OTTHUMP00000161516; OTTHUMP00000223184; OTTHUMP00000223187; major histocompatibility complex class I antigen-binding protein p88
 UniProt Protein Name    Calnexin
 UniProt Synonym Protein Names   
IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
 Protein Family    Calnexin
 UniProt Gene Name    CANX [Similar Products]
 UniProt Entry Name    CALX_HUMAN
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 NCBI Summary for CANX    This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
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 UniProt Comments for CANX    Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Protein type: Calcium-binding; Motility/polarity/chemotaxis; Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; membrane; rough endoplasmic reticulum; cell soma; endoplasmic reticulum; axon; endoplasmic reticulum lumen; dendritic spine; melanosome; ribosome

Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; carbohydrate binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging
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 Research Articles on CANX    1. HLA-I, TAP1, CNX, LMP7, Erp57, Tapasin and ERAP1 were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of esophageal squamous cell carcinoma lesions then, respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CANX antibodyPathways associated with anti-CANX antibody
 Reference Product  PubMed Publications
 HLA-A antibody  >1 publications with CANX and HLA-A
 PDIA3 antibody  >1 publications with CANX and PDIA3
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Assembly Of Viral Components At The Budding Site Pathway antibodies  Assembly Of Viral Components At The Budding Site Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-CANX antibodyOrgans/Tissues associated with anti-CANX antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with CANX and Adenocarcinoma
 Carcinoma Antibodies  >2 publications with CANX and Carcinoma
 Neoplasms Antibodies  >2 publications with CANX and Neoplasms
 Rectal Neoplasms Antibodies  >1 publications with CANX and Rectal Neoplasms
 Lung Diseases, Interstitial Antibodies  >1 publications with CANX and Lung Diseases, Interstitial
 Liver Neoplasms Antibodies  >1 publications with CANX and Liver Neoplasms
 Pleural Effusion Antibodies  >1 publications with CANX and Pleural Effusion
 Genital Diseases, Male Antibodies  >1 publications with CANX and Genital Diseases, Male
 Colorectal Neoplasms Antibodies  >1 publications with CANX and Colorectal Neoplasms
 Infertility, Male Antibodies  >1 publications with CANX and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with CANX and Lung
 Liver Antibodies  >2 publications with CANX and Liver
 Testis Antibodies  >2 publications with CANX and Testis
 Epididymis Antibodies  >1 publications with CANX and Epididymis
 Blood Antibodies  >1 publications with CANX and Blood
 Kidney Antibodies  >1 publications with CANX and Kidney
 Skin Antibodies  >1 publications with CANX and Skin
 Uterus Antibodies  >1 publications with CANX and Uterus
 Embryonic Tissue Antibodies  >1 publications with CANX and Embryonic Tissue
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