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anti-CAPN1 antibody :: Rabbit anti-Human Calpain-1 catalytic subunit Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493523
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calpain-1 catalytic subunit (CAPN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Calpain-1 catalytic subunit polyclonal Antibody(CAPN1)

 Product Synonym Names    Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP; CAPN1; CANPL1; PIG30
 Product Gene Name   

anti-CAPN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114220
 3D Structure    ModBase 3D Structure for P07384
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Calpain-1 catalytic subunit protein(1-714AA)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7531 / sc-31066 / sc-31065 / sc-7530 / sc-13990
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CAPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CAPN1 antibody

   Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
 Applications Tested/Suitable for anti-CAPN1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-CAPN1 antibody    Western blot
All lanes: CAPN1 antibody at 6ug/ml
Lane 1: A375 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: PC-3 whole cell lysate
Lane 4: Jurkat whole cell lysate
Lane 5: Hela whole cell lysate
Lane 6: A2780 whole cell lysate
Lane 7: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 82 kDa
Observed band size: 82 kDa

anti-CAPN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CAPN1 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS1493523 at dilution 1:100
anti-CAPN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CAPN1 antibody    Immunohistochemistry of paraffin-embedded human heart tissue using MBS1493523 at dilution 1:100
anti-CAPN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CAPN1. It may not necessarily be applicable to this product.
 NCBI GI #    311893363
 NCBI GeneID    823
 NCBI Accession #    NP_001185797.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198868.1 [Other Products]
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 UniProt Primary Accession #    P07384 [Other Products]
 UniProt Secondary Accession #    Q2TTR0; Q6DHV4 [Other Products]
 UniProt Related Accession #    P07384 [Other Products]
 Molecular Weight    81,890 Da
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 NCBI Official Full Name    calpain-1 catalytic subunit
 NCBI Official Synonym Full Names    calpain 1
 NCBI Official Symbol    CAPN1 [Similar Products]
 NCBI Official Synonym Symbols   
CANP; muCL; CANP1; CANPL1; muCANP
[Similar Products]
 NCBI Protein Information    calpain-1 catalytic subunit
 UniProt Protein Name    Calpain-1 catalytic subunit
 UniProt Synonym Protein Names   
Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP
 Protein Family    Calpain
 UniProt Gene Name    CAPN1 [Similar Products]
 UniProt Synonym Gene Names    CANPL1; CANP 1; muCANP [Similar Products]
 UniProt Entry Name    CAN1_HUMAN
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 NCBI Summary for CAPN1    The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for CAPN1    CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: EC 3.4.22.52; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; focal adhesion; lysosome; membrane; mitochondrion; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; protein binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; mammary gland involution; positive regulation of cell proliferation; proteolysis; receptor catabolic process
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 Research Articles on CAPN1    1. Data indicate that calpain is responsible for processing translation termination factor eRF3 into its IAP-binding isoform p-eRF3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CAPN1 antibodyPathways associated with anti-CAPN1 antibody
 Reference Product  PubMed Publications
 CAST antibody  >34 publications with CAPN1 and CAST
 CAPNS1 antibody  >15 publications with CAPN1 and CAPNS1
 PTPN1 antibody  >2 publications with CAPN1 and PTPN1
 SRC antibody  >1 publications with CAPN1 and SRC
 CASP12 antibody  >1 publications with CAPN1 and CASP12
 TLN1 antibody  >1 publications with CAPN1 and TLN1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
Diseases associated with anti-CAPN1 antibodyOrgans/Tissues associated with anti-CAPN1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with CAPN1 and Nervous System Diseases
 Heart Diseases Antibodies  >5 publications with CAPN1 and Heart Diseases
 Inflammation Antibodies  >5 publications with CAPN1 and Inflammation
 Necrosis Antibodies  >5 publications with CAPN1 and Necrosis
 Nerve Degeneration Antibodies  >4 publications with CAPN1 and Nerve Degeneration
 Fibrosis Antibodies  >4 publications with CAPN1 and Fibrosis
 Kidney Diseases Antibodies  >3 publications with CAPN1 and Kidney Diseases
 Weight Gain Antibodies  >3 publications with CAPN1 and Weight Gain
 Edema Antibodies  >2 publications with CAPN1 and Edema
 Weight Loss Antibodies  >2 publications with CAPN1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >52 publications with CAPN1 and Muscle
 Blood Antibodies  >23 publications with CAPN1 and Blood
 Brain Antibodies  >17 publications with CAPN1 and Brain
 Nerve Antibodies  >12 publications with CAPN1 and Nerve
 Eye Antibodies  >9 publications with CAPN1 and Eye
 Adipose Tissue Antibodies  >9 publications with CAPN1 and Adipose Tissue
 Vascular Antibodies  >7 publications with CAPN1 and Vascular
 Heart Antibodies  >7 publications with CAPN1 and Heart
 Skin Antibodies  >7 publications with CAPN1 and Skin
 Connective Tissue Antibodies  >6 publications with CAPN1 and Connective Tissue
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