AAH07553.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,275 Da
NCBI Official Full Name
Calpain 10
NCBI Official Synonym Full Names
calpain 10
NCBI Protein Information
calpain-10
UniProt Protein Name
Calpain-10
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 10; CANP 10
UniProt Synonym Gene Names
NCBI Summary for CAPN10
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
UniProt Comments for CAPN10
CAPN10: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1). It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the peptidase C2 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; EC 3.4.22.-; Mitochondrial; Protease
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytosol; mitochondrion; plasma membrane
Molecular Function: calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; SNARE binding
Biological Process: actin cytoskeleton reorganization; cell structure disassembly during apoptosis; cellular response to insulin stimulus; positive regulation of glucose import; positive regulation of insulin secretion; positive regulation of intracellular transport; positive regulation of type B pancreatic cell apoptotic process; proteolysis
Disease: Diabetes Mellitus, Noninsulin-dependent, 1
Research Articles on CAPN10
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Pathways associated with anti-CAPN10 antibody
Diseases associated with anti-CAPN10 antibody
Organs/Tissues associated with anti-CAPN10 antibody
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