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anti-CNR2 antibody :: Goat Cannabinoid Receptor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420135
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cannabinoid Receptor 2 (CNR2), Polyclonal Antibody

 Also Known As   

Goat anti-Cannabinoid Receptor 2 Antibody

 Product Synonym Names    CNR2; cannabinoid receptor 2 (macrophage); HGNC: 2160; CNR3; CB2; CX5; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2; cannabinoid receptor 2 (macrophage) antibody; HGNC: 2160 antibody; CNR3 antibody; CB2 antibody; CX5 antibody; OTTHUMP00000044841 antibody; CNR2 antibody; RP11-4M23.1 antibody; testis-dominant CNR2 isoform CB2 antibody; Cannabinoid Receptor 2; Cannabinoid Receptor 2
 Product Gene Name   

anti-CNR2 antibody

[Similar Products]
 Antibody/Peptide Pairs    Cannabinoid Receptor 2 peptide (MBS425975) is used for blocking the activity of Cannabinoid Receptor 2 antibody (MBS420135)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TETEADGKIT PWPD
 OMIM    605051
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TETEADGKITPWPD, from the C Terminus of the protein sequence according to NP_001832.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CNR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CNR2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CNR2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 40kDa band observed in Human Brain (Hippocampus) lysates (calculated MW of 46.2kDa according to NP_001832.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1.5-4.5ug/ml.
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 Western Blot (WB) of anti-CNR2 antibody    (1.5ug/ml) staining of Human Brain (Hippocampus) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CNR2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CNR2. It may not necessarily be applicable to this product.
 NCBI GI #    4502929
 NCBI GeneID    1269
 NCBI Accession #    NP_001832.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001841.2 [Other Products]
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 UniProt Secondary Accession #    Q4VBK8; Q5JRH7; Q6B0G7; Q6NSY0; C6ES44 [Other Products]
 UniProt Related Accession #    P34972 [Other Products]
 Molecular Weight    39,681 Da
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 NCBI Official Full Name    cannabinoid receptor 2
 NCBI Official Synonym Full Names    cannabinoid receptor 2
 NCBI Official Symbol    CNR2 [Similar Products]
 NCBI Official Synonym Symbols   
CB2; CX5; CB-2
[Similar Products]
 NCBI Protein Information    cannabinoid receptor 2
 UniProt Protein Name    Cannabinoid receptor 2
 UniProt Synonym Protein Names   
CX5
 Protein Family    Cannabinoid receptor
 UniProt Gene Name    CNR2 [Similar Products]
 UniProt Synonym Gene Names    CB2A; CB2B; CB-2; CB2; hCB2 [Similar Products]
 UniProt Entry Name    CNR2_HUMAN
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 NCBI Summary for CNR2    The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CNR2    CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: dendrite; extrinsic to internal side of plasma membrane; integral to plasma membrane; perikaryon; plasma membrane

Molecular Function: cannabinoid receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; inflammatory response; negative regulation of action potential; negative regulation of inflammatory response; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; response to amphetamine; response to lipopolysaccharide; sensory perception of pain
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 Research Articles on CNR2    1. CB2 receptor activation can attenuate HAND severity by inhibiting HIV replication, blunting HIV-triggered neuroinflammation, preventing HIV-induced damage to Blood-brain-barrier integrity, and preventing HIV-associated synapse loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNR2 antibodyPathways associated with anti-CNR2 antibody
 Reference Product  PubMed Publications
 GPR55 antibody  >7 publications with CNR2 and GPR55
 GPR18 antibody  >2 publications with CNR2 and GPR18
 OPRD1 antibody  >1 publications with CNR2 and OPRD1
 OPRM1 antibody  >1 publications with CNR2 and OPRM1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Small Ligand GPCRs Pathway antibodies  Small Ligand GPCRs Pathway Diagram
Diseases associated with anti-CNR2 antibodyOrgans/Tissues associated with anti-CNR2 antibody
 Disease Name  Pubmed Publications
 Pain Antibodies  >54 publications with CNR2 and Pain
 Inflammation Antibodies  >52 publications with CNR2 and Inflammation
 Disease Models, Animal Antibodies  >49 publications with CNR2 and Disease Models, Animal
 Immune System Diseases Antibodies  >21 publications with CNR2 and Immune System Diseases
 Necrosis Antibodies  >19 publications with CNR2 and Necrosis
 Hyperalgesia Antibodies  >19 publications with CNR2 and Hyperalgesia
 Liver Diseases Antibodies  >15 publications with CNR2 and Liver Diseases
 Heart Diseases Antibodies  >13 publications with CNR2 and Heart Diseases
 Edema Antibodies  >12 publications with CNR2 and Edema
 Fibrosis Antibodies  >10 publications with CNR2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with CNR2 and Blood
 Liver Antibodies  >26 publications with CNR2 and Liver
 Bone Marrow Antibodies  >8 publications with CNR2 and Bone Marrow
 Placenta Antibodies  >2 publications with CNR2 and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with CNR2 and Uncharacterized Tissue
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