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anti-CNR2 antibody :: Rabbit anti-Human Cannabinoid receptor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS851908
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cannabinoid receptor 2 (CNR2), Polyclonal Antibody

 Also Known As   

Cannabinoid receptor 2 Antibody

 Product Gene Name   

anti-CNR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605051
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized Cannabinoid receptor 2 antibody purified by protein A column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal Cannabinoid receptor 2 (1) antibody was raised against a recombinate human Cannabinoid receptor 2 protein 1-360aa (NM_001841).
 Reactivity Note    Predicted: Mouse, Rat; Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-CNR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CNR2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CNR2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CNR2 antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:1,000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-CNR2 antibody    anti-CNR2 antibody Testing Data image
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 Testing Data #2 of anti-CNR2 antibody    anti-CNR2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CNR2. It may not necessarily be applicable to this product.
 NCBI GI #    206725541
 NCBI GeneID    1269
 NCBI Accession #    NP_001832.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001841 [Other Products]
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 UniProt Secondary Accession #    Q4VBK8; Q5JRH7; Q6B0G7; Q6NSY0; C6ES44 [Other Products]
 UniProt Related Accession #    P34972 [Other Products]
 Molecular Weight    39,681 Da [Similar Products]
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 NCBI Official Full Name    Homo sapiens cannabinoid receptor 2 (macrophage) (CNR2), mRNA
 NCBI Official Synonym Full Names    cannabinoid receptor 2 (macrophage)
 NCBI Official Symbol    CNR2 [Similar Products]
 NCBI Official Synonym Symbols   
CB2; CX5; CB-2
[Similar Products]
 NCBI Protein Information    cannabinoid receptor 2; testis-dominant CNR2 isoform CB2
 UniProt Protein Name    Cannabinoid receptor 2
 UniProt Synonym Protein Names   
CX5
 Protein Family    Cannabinoid receptor
 UniProt Gene Name    CNR2 [Similar Products]
 UniProt Synonym Gene Names    CB2A; CB2B; CB-2; CB2; hCB2 [Similar Products]
 UniProt Entry Name    CNR2_HUMAN
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 NCBI Summary for CNR2    The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CNR2    CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extrinsic to internal side of plasma membrane; integral to plasma membrane; dendrite; plasma membrane; perikaryon

Molecular Function: cannabinoid receptor activity

Biological Process: negative regulation of mast cell activation; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of nitric-oxide synthase activity; negative regulation of inflammatory response; response to amphetamine; immune response; response to lipopolysaccharide; negative regulation of action potential; sensory perception of pain; negative regulation of synaptic transmission, GABAergic; inflammatory response
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 Research Articles on CNR2    1. association of the minor allele of SNP rs3123554 within the CNR2 gene with lower BMI and body fat; significant association of the SNP with BMI was limited to females
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNR2 antibodyPathways associated with anti-CNR2 antibody
 Reference Product  PubMed Publications
 FAAH antibody  >16 publications with CNR2 and FAAH
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Small Ligand GPCRs Pathway antibodies  Small Ligand GPCRs Pathway Diagram
Diseases associated with anti-CNR2 antibodyOrgans/Tissues associated with anti-CNR2 antibody
 Disease Name  Pubmed Publications
 Pain Antibodies  >47 publications with CNR2 and Pain
 Inflammation Antibodies  >39 publications with CNR2 and Inflammation
 Disease Models, Animal Antibodies  >33 publications with CNR2 and Disease Models, Animal
 Hyperalgesia Antibodies  >17 publications with CNR2 and Hyperalgesia
 Immune System Diseases Antibodies  >15 publications with CNR2 and Immune System Diseases
 Necrosis Antibodies  >14 publications with CNR2 and Necrosis
 Heart Diseases Antibodies  >11 publications with CNR2 and Heart Diseases
 Edema Antibodies  >10 publications with CNR2 and Edema
 Fibrosis Antibodies  >6 publications with CNR2 and Fibrosis
 Fatty Liver Antibodies  >4 publications with CNR2 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CNR2 and Blood
 Liver Antibodies  >18 publications with CNR2 and Liver
 Bone Marrow Antibodies  >5 publications with CNR2 and Bone Marrow
 Placenta Antibodies  >2 publications with CNR2 and Placenta
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