NP_064336.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,261 Da
NCBI Official Full Name
cardiotrophin-like cytokine factor 1
NCBI Official Synonym Full Names
cardiotrophin-like cytokine factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
cardiotrophin-like cytokine factor 1; BSF-3; NNT-1; NNT-1/BSF-3; novel neurotrophin-1; B-cell stimulating factor 3; B-cell-stimulating factor 3; b cell-stimulating factor 3; neurotrophin-1/B-cell stimulating factor-3
UniProt Protein Name
Cardiotrophin-like cytokine factor 1
UniProt Synonym Protein Names
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1
UniProt Synonym Gene Names
UniProt Entry Name
CLCF1_MOUSE
UniProt Comments for CLCF1
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Secreted; Apoptosis; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region; intracellular
Molecular Function: protein binding; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding
Biological Process: positive regulation of T-helper 2 type immune response; regulation of protein kinase B signaling cascade; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of corticotropin-releasing hormone secretion; positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; positive regulation of cell proliferation; regulation of inflammatory response; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation
Research Articles on CLCF1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CLCF1 antibody
Pathways associated with anti-CLCF1 antibody
Diseases associated with anti-CLCF1 antibody
Organs/Tissues associated with anti-CLCF1 antibody
|