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anti-CSNK2A2 antibody :: Rabbit anti-Human Casein kinase II subunit alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489739 anti-CSNK2A2 antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Casein kinase II subunit alpha (CSNK2A2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Casein kinase II subunit alpha' polyclonal Antibody, FITC

 Product Synonym Names    CSNK2A2 CK2A2
 Product Gene Name   

anti-CSNK2A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    115442
 3D Structure    ModBase 3D Structure for P19784
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    FITC
 Immunogen    Recombinant human Casein kinase II subunit alpha' protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6481
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CSNK2A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CSNK2A2 antibody

   Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
 Applications Tested/Suitable for anti-CSNK2A2 antibody   

Western Blot (WB), ELISA (EIA). Not yet tested in other applications.

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NCBI/Uniprot data below describe general gene information for CSNK2A2. It may not necessarily be applicable to this product.
 NCBI GI #    4503097
 NCBI GeneID    1459
 NCBI Accession #    NP_001887.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001896.2 [Other Products]
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 UniProt Primary Accession #    P19784 [Other Products]
 UniProt Related Accession #    P19784 [Other Products]
 Molecular Weight    41,213 Da [Similar Products]
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 NCBI Official Full Name    casein kinase II subunit alpha'
 NCBI Official Synonym Full Names    casein kinase 2 alpha 2
 NCBI Official Symbol    CSNK2A2 [Similar Products]
 NCBI Official Synonym Symbols   
CK2A2; CSNK2A1
[Similar Products]
 NCBI Protein Information    casein kinase II subunit alpha'
 UniProt Protein Name    Casein kinase II subunit alpha'
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK2A2 [Similar Products]
 UniProt Synonym Gene Names    CK2A2; CK II alpha' [Similar Products]
 UniProt Entry Name    CSK22_HUMAN
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 UniProt Comments for CSNK2A2    CK2A2: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; CK2 family

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cytosol; nucleus; PcG protein complex

Molecular Function: ATP binding; protein binding; protein N-terminus binding; protein serine/threonine kinase activity

Biological Process: apoptosis; axon guidance; mitotic cell cycle; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; Wnt receptor signaling pathway
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 Research Articles on CSNK2A2    1. CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and may have role in malignant B-cell growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSNK2A2 antibodyPathways associated with anti-CSNK2A2 antibody
 Reference Product  PubMed Publications
 MYC antibody  >1 publications with CSNK2A2 and MYC
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-CSNK2A2 antibodyOrgans/Tissues associated with anti-CSNK2A2 antibody
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >5 publications with CSNK2A2 and Infertility, Male
 Heart Diseases Antibodies  >3 publications with CSNK2A2 and Heart Diseases
 Colonic Neoplasms Antibodies  >2 publications with CSNK2A2 and Colonic Neoplasms
 Brain Diseases Antibodies  >1 publications with CSNK2A2 and Brain Diseases
 Neoplasms, Experimental Antibodies  >1 publications with CSNK2A2 and Neoplasms, Experimental
 Oligospermia Antibodies  >1 publications with CSNK2A2 and Oligospermia
 Breast Neoplasms Antibodies  >1 publications with CSNK2A2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with CSNK2A2 and Blood
 Heart Antibodies  >3 publications with CSNK2A2 and Heart
 Muscle Antibodies  >2 publications with CSNK2A2 and Muscle
 Prostate Antibodies  >2 publications with CSNK2A2 and Prostate
 Lung Antibodies  >2 publications with CSNK2A2 and Lung
 Testis Antibodies  >2 publications with CSNK2A2 and Testis
 Brain Antibodies  >2 publications with CSNK2A2 and Brain
 Kidney Antibodies  >1 publications with CSNK2A2 and Kidney
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