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anti-CASP1 antibody :: Rabbit anti-Porcine Caspase 1 (CASP1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2002145 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $250 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
1 mg  /  $910 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase 1 (CASP1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Caspase 1 (CASP1)

 Product Gene Name   

anti-CASP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-N PVKPASSEPR GSLKLCPPDI AQRLWKEKSA EIYPIMGKSI RTRLALIICN TEFENLPRRD GADVDIRDMK ILLEDLGYSV DVRENLTASD MAIELKAFAA RPEHKSSDST FLVLMSHGIQ AGICGKKYSE EVPDVLEVNT VFQILNTLNC PSLKDKPKVI IIQACRGEKQ GVVWIKD
 3D Structure    ModBase 3D Structure for Q9N2I1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Porcine
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 Specificity    The antibody is a rabbit polyclonal antibody raised against CASP1. It has been selected for its ability to recognize CASP1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant CASP1 (Asn120~Asp297) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2056879
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-CASP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CASP1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-CASP1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CASP1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-CASP1 antibody    Knockout Verification: Lane 1: Wild-type Raji cell lysate
Lane 2: CASP1 knockout Raji cell lysate
Predicted MW: 10,30,35,43,45kDa ;Observed MW: 42kDa;Primary Ab: 5ug/ml Rabbit Anti-Porcine CASP1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;
anti-CASP1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-CASP1 antibody    Western Blot; Sample. Lane1: Porcine Spleen Tissue ; Lane2: Porcine Lung Tissue; Lane3: Human Hela Cells; Lane4: Human Raji Cells.
anti-CASP1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CASP1 antibody    Western Blot; Sample: Recombinant protein.
anti-CASP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CASP1. It may not necessarily be applicable to this product.
 NCBI GI #    47523412
 NCBI GeneID    397319
 NCBI Accession #    NP_999327.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_214162.1 [Other Products]
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 UniProt Primary Accession #    Q9N2I1 [Other Products]
 UniProt Related Accession #    Q9N2I1 [Other Products]
 Molecular Weight    44,882 Da
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 NCBI Official Full Name    caspase-1
 NCBI Official Symbol    CASP1 [Similar Products]
 NCBI Protein Information    caspase-1
 UniProt Protein Name    Caspase-1
 UniProt Synonym Protein Names   
Interleukin-1 beta convertase; IL-1BC
 UniProt Gene Name    CASP1 [Similar Products]
 UniProt Synonym Gene Names    IL1BC; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme [Similar Products]
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 UniProt Comments for CASP1    Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive.
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 Research Articles on CASP1    1. mmediately after hypoxia C8 and C1 follow a similar pattern of increase while long term this appears to dissociate
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CASP1 antibodyDiseases associated with anti-CASP1 antibody
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >780 publications with CASP1 and Inflammation
 Necrosis Antibodies  >504 publications with CASP1 and Necrosis
 Neoplasms Antibodies  >383 publications with CASP1 and Neoplasms
 Nervous System Diseases Antibodies  >297 publications with CASP1 and Nervous System Diseases
 Brain Diseases Antibodies  >228 publications with CASP1 and Brain Diseases
 Drug Toxicity Antibodies  >180 publications with CASP1 and Drug Toxicity
 Gastrointestinal Diseases Antibodies  >114 publications with CASP1 and Gastrointestinal Diseases
 Carcinoma Antibodies  >101 publications with CASP1 and Carcinoma
 Liver Diseases Antibodies  >78 publications with CASP1 and Liver Diseases
 Brain Ischemia Antibodies  >72 publications with CASP1 and Brain Ischemia
Organs/Tissues associated with anti-CASP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >755 publications with CASP1 and Blood
 Lung Antibodies  >132 publications with CASP1 and Lung
 Skin Antibodies  >109 publications with CASP1 and Skin
 Intestine Antibodies  >79 publications with CASP1 and Intestine
 Thymus Antibodies  >29 publications with CASP1 and Thymus
 Uterus Antibodies  >14 publications with CASP1 and Uterus
 Aorta Antibodies  >9 publications with CASP1 and Aorta
 Oviduct Antibodies  >7 publications with CASP1 and Oviduct
 Bladder Antibodies  >4 publications with CASP1 and Bladder
 Esophagus Antibodies  >3 publications with CASP1 and Esophagus
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