NP_001214.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
caspase-1 isoform beta
NCBI Official Synonym Full Names
caspase 1, apoptosis-related cysteine peptidase
NCBI Protein Information
caspase-1
UniProt Protein Name
Caspase-1
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC
UniProt Synonym Gene Names
IL1BC; IL1BCE; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme [Similar Products]
UniProt Entry Name
CASP1_HUMAN
NCBI Summary for CASP1
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
UniProt Comments for CASP1
CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Protease; EC 3.4.22.36
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: cytoplasm; extracellular region; cytosol
Molecular Function: protein binding; cysteine-type endopeptidase activity; endopeptidase activity; caspase activator activity
Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; membrane hyperpolarization; interleukin-1 beta production; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; mitochondrial depolarization; signal transduction; proteolysis; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of inflammatory response; response to hypoxia; innate immune response; regulation of autophagy
Product References and Citations for anti-CASP1 antibody
Thornberry N.A.,et al.Nature 356:768-774(1992). Cerretti D.P.,et al.Science 256:97-100(1992). Alnemri E.S.,et al.J. Biol. Chem. 270:4312-4317(1995). Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Taylor T.D.,et al.Nature 440:497-500(2006).
Research Articles on CASP1
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Products associated with anti-CASP1 antibody
Pathways associated with anti-CASP1 antibody
Diseases associated with anti-CASP1 antibody
Organs/Tissues associated with anti-CASP1 antibody
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