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anti-Casp2 antibody :: Rabbit anti-Human Caspase-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2539198
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase-2 (Casp2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Caspase-2 Polyclonal Antibody

 Product Synonym Names    CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1
 Product Gene Name   

anti-Casp2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from human Caspase-2 around the non-phosphorylation site of S157.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Casp2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Casp2 antibody    Cell biology
 Applications Tested/Suitable for anti-Casp2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-Casp2 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-Casp2 antibody    Western Blot analysis of various cells with Caspase-2 Polyclonal Antibody.
anti-Casp2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Casp2. It may not necessarily be applicable to this product.
 NCBI GI #    19923687
 NCBI GeneID    64314
 NCBI Accession #    NP_071967.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022522.2 [Other Products]
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 UniProt Secondary Accession #    O35398; O55194; Q9WUI6 [Other Products]
 UniProt Related Accession #    P55215 [Other Products]
 Molecular Weight    Calculated MW: 51
Observed MW: 51
[Similar Products]
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 NCBI Official Full Name    caspase-2
 NCBI Official Synonym Full Names    caspase 2
 NCBI Official Symbol    Casp2 [Similar Products]
 NCBI Protein Information    caspase-2
 UniProt Protein Name    Caspase-2
 UniProt Synonym Protein Names   
Protease ICH-1
 Protein Family    Caspase
 UniProt Gene Name    Casp2 [Similar Products]
 UniProt Synonym Gene Names    Ich1; CASP-2 [Similar Products]
 UniProt Entry Name    CASP2_RAT
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 NCBI Summary for Casp2    may play a role in proteolysis and programmed cell death [RGD, Feb 2006]
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 UniProt Comments for Casp2    CASP2: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.22.55; Apoptosis

Cellular Component: cytoplasm; membrane; mitochondrion; nucleus

Molecular Function: cysteine-type endopeptidase activity; protein binding; protein domain specific binding

Biological Process: aging; apoptosis; brain development; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; germ cell programmed cell death; luteolysis; positive regulation of apoptosis; positive regulation of neuron apoptosis; programmed cell death; protein processing; proteolysis; regulation of apoptosis
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 Research Articles on Casp2    1. SiRNA-mediated downregulation of CASP2 protected 50% of DRGN from apoptosis after serum withdrawal.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Casp2 antibodyPathways associated with anti-Casp2 antibody
 Reference Product  PubMed Publications
 Casp3 antibody  >52 publications with Casp2 and Casp3
 Apaf1 antibody  >6 publications with Casp2 and Apaf1
 Xiap antibody  >6 publications with Casp2 and Xiap
 Ngf antibody  >2 publications with Casp2 and Ngf
 Birc3 antibody  >2 publications with Casp2 and Birc3
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Cardiovascular Signaling Pathway antibodies  Cardiovascular Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
Diseases associated with anti-Casp2 antibodyOrgans/Tissues associated with anti-Casp2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with Casp2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >11 publications with Casp2 and Disease Models, Animal
 Inflammation Antibodies  >10 publications with Casp2 and Inflammation
 Brain Diseases Antibodies  >9 publications with Casp2 and Brain Diseases
 Necrosis Antibodies  >9 publications with Casp2 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >6 publications with Casp2 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >6 publications with Casp2 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >5 publications with Casp2 and Ovarian Neoplasms
 Lung Diseases Antibodies  >5 publications with Casp2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >5 publications with Casp2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with Casp2 and Brain
 Liver Antibodies  >8 publications with Casp2 and Liver
 Lung Antibodies  >7 publications with Casp2 and Lung
 Prostate Antibodies  >4 publications with Casp2 and Prostate
 Embryonic Tissue Antibodies  >4 publications with Casp2 and Embryonic Tissue
 Thymus Antibodies  >2 publications with Casp2 and Thymus
 Heart Antibodies  >2 publications with Casp2 and Heart
 Spleen Antibodies  >1 publications with Casp2 and Spleen
 Ovary Antibodies  >1 publications with Casp2 and Ovary
 Connective Tissue Antibodies  >1 publications with Casp2 and Connective Tissue
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