NP_071967.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
caspase-2
NCBI Official Synonym Full Names
caspase 2
NCBI Protein Information
caspase-2
UniProt Protein Name
Caspase-2
UniProt Synonym Protein Names
Protease ICH-1
UniProt Synonym Gene Names
UniProt Entry Name
CASP2_RAT
NCBI Summary for Casp2
may play a role in proteolysis and programmed cell death [RGD, Feb 2006]
UniProt Comments for Casp2
CASP2: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.22.55; Apoptosis
Cellular Component: cytoplasm; membrane; mitochondrion; nucleus
Molecular Function: cysteine-type endopeptidase activity; protein binding; protein domain specific binding
Biological Process: aging; apoptosis; brain development; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; germ cell programmed cell death; luteolysis; positive regulation of apoptosis; positive regulation of neuron apoptosis; programmed cell death; protein processing; proteolysis; regulation of apoptosis
Research Articles on Casp2
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Products associated with anti-Casp2 antibody
Pathways associated with anti-Casp2 antibody
Diseases associated with anti-Casp2 antibody
Organs/Tissues associated with anti-Casp2 antibody
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