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anti-CASP3 antibody :: Rabbit Caspase-3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2535040
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase-3 (CASP3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Caspase-3 Polyclonal Antibody

 Product Synonym Names    CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
 Product Gene Name   

anti-CASP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600636
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human Caspase-3.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CASP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CASP3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CASP3 antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-CASP3 antibody    Western Blot analysis of various cells using Caspase-3 Polyclonal Antibody at dilution of 1:1000.
anti-CASP3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CASP3 antibody    Immunohistochemistry of paraffin-embedded Rat kidney tissue using Caspase-3 Polyclonal Antibody at dilution of 1:200.
anti-CASP3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CASP3 antibody    Immunofluorescence analysis of Rat lung tissue using Caspase-3 Polyclonal Antibody at dilution of 1:200.
anti-CASP3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CASP3. It may not necessarily be applicable to this product.
 NCBI GI #    14790119
 NCBI GeneID    836
 NCBI Accession #    NP_004337.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004346.3 [Other Products]
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 UniProt Secondary Accession #    Q96AN1; Q96KP2; A8K5M2; D3DP53 [Other Products]
 UniProt Related Accession #    P42574 [Other Products]
 Molecular Weight    Calculated MW: 32
Observed MW: 35
[Similar Products]
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 NCBI Official Full Name    caspase-3 preproprotein
 NCBI Official Synonym Full Names    caspase 3
 NCBI Official Symbol    CASP3 [Similar Products]
 NCBI Official Synonym Symbols   
CPP32; SCA-1; CPP32B
[Similar Products]
 NCBI Protein Information    caspase-3
 UniProt Protein Name    Caspase-3
 UniProt Synonym Protein Names   
Apopain; Cysteine protease CPP32; CPP-32
 Protein Family    Caspase
 UniProt Gene Name    CASP3 [Similar Products]
 UniProt Synonym Gene Names    CPP32; CASP-3; CPP-32; SCA-1 [Similar Products]
 UniProt Entry Name    CASP3_HUMAN
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 NCBI Summary for CASP3    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASP3    CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family.

Protein type: Apoptosis; Protease; Motility/polarity/chemotaxis; EC 3.4.22.56

Chromosomal Location of Human Ortholog: 4q34

Cellular Component: cytosol; lipid raft; nucleoplasm; nucleus; plasma membrane

Molecular Function: cyclin-dependent protein kinase inhibitor activity; cysteine-type endopeptidase activity; death receptor binding; peptidase activity; phospholipase A2 activator activity; protease binding; protein binding; protein complex binding

Biological Process: apoptosis; B cell homeostasis; caspase activation via cytochrome c; cell fate commitment; cell structure disassembly during apoptosis; DNA fragmentation during apoptosis; erythrocyte differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; heart development; hippocampus development; keratinocyte differentiation; learning and/or memory; negative regulation of activated T cell proliferation; negative regulation of apoptosis; negative regulation of B cell proliferation; negative regulation of cyclin-dependent protein kinase activity; nerve growth factor receptor signaling pathway; neuron apoptosis; neuron differentiation; platelet formation; positive regulation of neuron apoptosis; programmed cell death; proteolysis; regulation of caspase activity; response to amino acid stimulus; response to antibiotic; response to cobalt ion; response to DNA damage stimulus; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; response to UV; response to X-ray; sensory perception of sound; T cell homeostasis; wound healing
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 Research Articles on CASP3    1. The purpose of this study was to comprehensively investigate the association between common genetic variants of CASP3 gene and AF in Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CASP3 antibodyPathways associated with anti-CASP3 antibody
 Reference Product  PubMed Publications
 CASP9 antibody  >6744 publications with CASP3 and CASP9
 CASP8 antibody  >4866 publications with CASP3 and CASP8
 XIAP antibody  >931 publications with CASP3 and XIAP
 CASP6 antibody  >453 publications with CASP3 and CASP6
 PARP1 antibody  >393 publications with CASP3 and PARP1
 APAF1 antibody  >330 publications with CASP3 and APAF1
 GZMB antibody  >149 publications with CASP3 and GZMB
 BIRC3 antibody  >42 publications with CASP3 and BIRC3
 BIRC2 antibody  >36 publications with CASP3 and BIRC2
 DFFA antibody  >4 publications with CASP3 and DFFA
 Products by Pathway  Pathway Diagram
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 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
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 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with anti-CASP3 antibodyOrgans/Tissues associated with anti-CASP3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >6011 publications with CASP3 and Necrosis
 Nervous System Diseases Antibodies  >4614 publications with CASP3 and Nervous System Diseases
 Inflammation Antibodies  >3029 publications with CASP3 and Inflammation
 Reperfusion Injury Antibodies  >2021 publications with CASP3 and Reperfusion Injury
 Liver Diseases Antibodies  >1979 publications with CASP3 and Liver Diseases
 Brain Ischemia Antibodies  >1460 publications with CASP3 and Brain Ischemia
 Heart Diseases Antibodies  >1359 publications with CASP3 and Heart Diseases
 Breast Neoplasms Antibodies  >1278 publications with CASP3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1154 publications with CASP3 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >760 publications with CASP3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6784 publications with CASP3 and Brain
 Blood Antibodies  >6783 publications with CASP3 and Blood
 Liver Antibodies  >3660 publications with CASP3 and Liver
 Muscle Antibodies  >3009 publications with CASP3 and Muscle
 Vascular Antibodies  >2875 publications with CASP3 and Vascular
 Lung Antibodies  >2818 publications with CASP3 and Lung
 Heart Antibodies  >2594 publications with CASP3 and Heart
 Kidney Antibodies  >1798 publications with CASP3 and Kidney
 Bone Antibodies  >1544 publications with CASP3 and Bone
 Prostate Antibodies  >1128 publications with CASP3 and Prostate
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