ABW03582.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,953 Da
NCBI Official Full Name
caspase recruitment domain family, member 9, partial
NCBI Official Synonym Full Names
caspase recruitment domain family member 9
NCBI Protein Information
caspase recruitment domain-containing protein 9
UniProt Protein Name
Caspase recruitment domain-containing protein 9
UniProt Synonym Gene Names
NCBI Summary for CARD9
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]
UniProt Comments for CARD9
CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: CARD domain binding; protein binding; protein homodimerization activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; stimulatory C-type lectin receptor signaling pathway
Disease: Candidiasis, Familial, 2
Research Articles on CARD9
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Products associated with anti-CARD9 antibody
Pathways associated with anti-CARD9 antibody
Diseases associated with anti-CARD9 antibody
Disease Name |
Pubmed Publications |
Inflammation Antibodies |
>50 publications with CARD9 and Inflammation |
Skin Diseases Antibodies |
>39 publications with CARD9 and Skin Diseases |
Necrosis Antibodies |
>22 publications with CARD9 and Necrosis |
Autoimmune Diseases Antibodies |
>19 publications with CARD9 and Autoimmune Diseases |
Inflammatory Bowel Diseases Antibodies |
>16 publications with CARD9 and Inflammatory Bowel Diseases |
Disease Models, Animal Antibodies |
>10 publications with CARD9 and Disease Models, Animal |
Colitis, Ulcerative Antibodies |
>9 publications with CARD9 and Colitis, Ulcerative |
Spondylitis, Ankylosing Antibodies |
>6 publications with CARD9 and Spondylitis, Ankylosing |
Fibrosis Antibodies |
>4 publications with CARD9 and Fibrosis |
CANDIDIASIS, FAMILIAL, 2 Antibodies |
>4 publications with CARD9 and CANDIDIASIS, FAMILIAL, 2 |
Organs/Tissues associated with anti-CARD9 antibody
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