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anti-COMT antibody :: Rabbit anti-Human Catechol O-methyltransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489377
Immunofluorescence (IF)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Catechol O-methyltransferase (COMT), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Catechol O-methyltransferase polyclonal Antibody

 Product Gene Name   

anti-COMT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611451
 3D Structure    ModBase 3D Structure for Q8WZ04
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Catechol O-methyltransferase
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COMT antibody

   Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
 Applications Tested/Suitable for anti-COMT antibody   

ELISA (EIA), Immunofluorescence (IF)

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 Immunofluorescence (IF) of anti-COMT antibody    Immunofluorescent analysis of HepG2 cells using MBS1489377 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-COMT antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for COMT. It may not necessarily be applicable to this product.
 NCBI GI #    223718159
 NCBI GeneID    220074
 NCBI Accession #    NP_001138780.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145308.4 [Other Products]
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 UniProt Primary Accession #    Q8WZ04 [Other Products]
 UniProt Secondary Accession #    B7Z816 [Other Products]
 UniProt Related Accession #    Q96E66; Q8WZ04 [Other Products]
 Molecular Weight    27,548 Da
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 NCBI Official Full Name    transmembrane O-methyltransferase isoform LRTOMT2a
 NCBI Official Synonym Full Names    leucine rich transmembrane and O-methyltransferase domain containing
 NCBI Official Symbol    LRTOMT [Similar Products]
 NCBI Official Synonym Symbols   
DFNB63; LRRC51; CFAP111
[Similar Products]
 NCBI Protein Information    leucine-rich repeat-containing protein 51; transmembrane O-methyltransferase
 UniProt Protein Name    Transmembrane O-methyltransferase
 UniProt Synonym Protein Names   
Catechol O-methyltransferase 2
 Protein Family    Catechol O-methyltransferase
 UniProt Gene Name    LRTOMT [Similar Products]
 UniProt Synonym Gene Names    [Similar Products]
 UniProt Entry Name    TOMT_HUMAN
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 NCBI Summary for COMT    This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]
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 UniProt Comments for COMT    LRTOMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Defects in LRTOMT are the cause of deafness autosomal recessive type 63 (DFNB63). A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Cell development/differentiation; Membrane protein, integral; EC 2.1.1.6

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: cytoplasm; integral to membrane

Molecular Function: catechol O-methyltransferase activity

Biological Process: auditory receptor cell development; catecholamine catabolic process; methylation; neurotransmitter catabolic process; sensory perception of sound

Disease: Deafness, Autosomal Recessive 63
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 Research Articles on COMT    1. Results indicate that mutations in the LRT)MT gene lead to alterations in the LRTOMT2 protein and might be involved in progressive sensorineural hearing loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COMT antibodyPathways associated with anti-COMT antibody
 Reference Product  PubMed Publications
 TMC1 antibody  >2 publications with COMT and TMC1
 Products by Pathway  Pathway Diagram
 Noradrenaline And Adrenaline Degradation Pathway antibodies  Noradrenaline And Adrenaline Degradation Pathway Diagram
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