AAC37547.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cathepsin B
NCBI Official Synonym Full Names
cathepsin B
NCBI Official Synonym Symbols
NCBI Protein Information
cathepsin B
UniProt Protein Name
Cathepsin B
UniProt Synonym Protein Names
APP secretase; APPS
UniProt Synonym Gene Names
UniProt Entry Name
CATB_HUMAN
NCBI Summary for CTSB
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CTSB
CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.
Protein type: Motility/polarity/chemotaxis; EC 3.4.22.1; Autophagy; Protease
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: extracellular space; mitochondrion; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; melanosome; extracellular region; nucleolus; intracellular
Molecular Function: peptidase activity; collagen binding; protein binding; proteoglycan binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis involved in cellular protein catabolic process; epithelial cell differentiation; regulation of catalytic activity; toll-like receptor signaling pathway; innate immune response; decidualization; proteolysis
Research Articles on CTSB
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Products associated with anti-CTSB antibody
Pathways associated with anti-CTSB antibody
Diseases associated with anti-CTSB antibody
Organs/Tissues associated with anti-CTSB antibody
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