P07858.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,822 Da
NCBI Official Full Name
Cathepsin B
NCBI Official Synonym Full Names
cathepsin B
NCBI Official Synonym Symbols
NCBI Protein Information
cathepsin B
UniProt Protein Name
Cathepsin B
UniProt Synonym Protein Names
APP secretase; APPS
UniProt Synonym Gene Names
UniProt Entry Name
CATB_HUMAN
NCBI Summary for CTSB
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
UniProt Comments for CTSB
CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.
Protein type: Motility/polarity/chemotaxis; Protease; Autophagy; EC 3.4.22.1
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: apical plasma membrane; caveola; external side of plasma membrane; extracellular region; extracellular space; intracellular; intracellular membrane-bound organelle; lysosome; melanosome; mitochondrion; nucleolus; perinuclear region of cytoplasm; sarcolemma
Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding; protein self-association; proteoglycan binding
Biological Process: autophagy; collagen catabolic process; decidualization; entry of virus into host cell; epithelial cell differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; innate immune response; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of apoptosis; regulation of catalytic activity; response to amine stimulus; response to ethanol; response to glucose stimulus; response to organic cyclic substance; response to peptide hormone stimulus; response to wounding; skeletal muscle development; spermatogenesis; toll-like receptor signaling pathway
Research Articles on CTSB
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Pathways associated with anti-CTSB antibody
Diseases associated with anti-CTSB antibody
Organs/Tissues associated with anti-CTSB antibody
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