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anti-CTSB antibody :: Rabbit Cathepsin B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8242605
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin B (CTSB), Polyclonal Antibody

 Also Known As   

Anti-Cathepsin B Antibody

 Product Synonym Names    CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1
 Product Gene Name   

anti-CTSB antibody

[Similar Products]
 Antibody/Peptide Pairs    Cathepsin B peptide (MBS8243968) is used for blocking the activity of Cathepsin B antibody (MBS8242605)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116810
 3D Structure    ModBase 3D Structure for P07858
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Specificity    Recognizes endogenous levels of Cathepsin B protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin B. The exact sequence is proprietary.
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 Preparation and Storage    Shipped and store at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CTSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CTSB antibody

   Rabbit polyclonal antibody to Cathepsin B
 Applications Tested/Suitable for anti-CTSB antibody   

Western Blot (WB)

 Application Notes for anti-CTSB antibody    Western Blot: (1/500 - 1/1000)
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 Western Blot (WB) of anti-CTSB antibody    Western blot analysis of Cathepsin B expression in A549 (A), HT1080 (B), mouse heart (C) whole cell lysates.
anti-CTSB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CTSB. It may not necessarily be applicable to this product.
 NCBI GI #    68067549
 NCBI GeneID    1508; 13030
 NCBI Accession #    P07858.3 [Other Products]
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 UniProt Primary Accession #    P07858 [Other Products]
 UniProt Secondary Accession #    Q503A6; Q96D87; B3KQR5; B3KRR5 [Other Products]
 UniProt Related Accession #    P07858 [Other Products]
 Molecular Weight    37,822 Da
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 NCBI Official Full Name    Cathepsin B
 NCBI Official Synonym Full Names    cathepsin B
 NCBI Official Symbol    CTSB [Similar Products]
 NCBI Official Synonym Symbols   
APPS; CPSB
[Similar Products]
 NCBI Protein Information    cathepsin B
 UniProt Protein Name    Cathepsin B
 UniProt Synonym Protein Names   
APP secretase; APPS
 Protein Family    Cathepsin
 UniProt Gene Name    CTSB [Similar Products]
 UniProt Synonym Gene Names    CPSB; APPS [Similar Products]
 UniProt Entry Name    CATB_HUMAN
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 NCBI Summary for CTSB    This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
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 UniProt Comments for CTSB    CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.

Protein type: Motility/polarity/chemotaxis; Protease; Autophagy; EC 3.4.22.1

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: apical plasma membrane; caveola; external side of plasma membrane; extracellular region; extracellular space; intracellular; intracellular membrane-bound organelle; lysosome; melanosome; mitochondrion; nucleolus; perinuclear region of cytoplasm; sarcolemma

Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding; protein self-association; proteoglycan binding

Biological Process: autophagy; collagen catabolic process; decidualization; entry of virus into host cell; epithelial cell differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; innate immune response; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of apoptosis; regulation of catalytic activity; response to amine stimulus; response to ethanol; response to glucose stimulus; response to organic cyclic substance; response to peptide hormone stimulus; response to wounding; skeletal muscle development; spermatogenesis; toll-like receptor signaling pathway
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 Research Articles on CTSB    1. High cathepsin is associated with drug resistance in neuroblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CTSB antibodyDiseases associated with anti-CTSB antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >44 publications with CTSB and Inflammation
 Disease Models, Animal Antibodies  >37 publications with CTSB and Disease Models, Animal
 Nervous System Diseases Antibodies  >32 publications with CTSB and Nervous System Diseases
 Necrosis Antibodies  >31 publications with CTSB and Necrosis
 Brain Diseases Antibodies  >22 publications with CTSB and Brain Diseases
 Cardiovascular Diseases Antibodies  >22 publications with CTSB and Cardiovascular Diseases
 Liver Diseases Antibodies  >20 publications with CTSB and Liver Diseases
 Neoplasm Invasiveness Antibodies  >19 publications with CTSB and Neoplasm Invasiveness
 Disease Progression Antibodies  >17 publications with CTSB and Disease Progression
 Lung Neoplasms Antibodies  >15 publications with CTSB and Lung Neoplasms
Organs/Tissues associated with anti-CTSB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >65 publications with CTSB and Blood
 Liver Antibodies  >33 publications with CTSB and Liver
 Brain Antibodies  >33 publications with CTSB and Brain
 Lung Antibodies  >27 publications with CTSB and Lung
 Bone Antibodies  >18 publications with CTSB and Bone
 Muscle Antibodies  >17 publications with CTSB and Muscle
 Vascular Antibodies  >16 publications with CTSB and Vascular
 Skin Antibodies  >14 publications with CTSB and Skin
 Bone Marrow Antibodies  >12 publications with CTSB and Bone Marrow
 Pancreas Antibodies  >12 publications with CTSB and Pancreas
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