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anti-CTSC antibody :: Rabbit anti-Human Cathepsin C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536107
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin C (CTSC), Polyclonal Antibody

 Also Known As   

Cleaved-Cathepsin C HC (R394) Polyclonal Antibody

 Product Synonym Names    CTSC; CPPI; Dipeptidyl peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase
 Product Gene Name   

anti-CTSC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    170650
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human Cathepsin C HC.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CTSC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CTSC antibody    Cell biology
 Applications Tested/Suitable for anti-CTSC antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CTSC antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-CTSC antibody    Western Blot analysis of various cells with Cleaved-Cathepsin C HC (R394) Polyclonal Antibody.
anti-CTSC antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CTSC. It may not necessarily be applicable to this product.
 NCBI GI #    33327024
 NCBI GeneID    1075
 NCBI Accession #    AAQ08887.1 [Other Products]
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 UniProt Secondary Accession #    Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; A8K7V2; B5MDD5 [Other Products]
 UniProt Related Accession #    P53634 [Other Products]
 Molecular Weight    Calculated MW: 52
Observed MW: 27
[Similar Products]
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 NCBI Official Full Name    cathepsin C
 NCBI Official Synonym Full Names    cathepsin C
 NCBI Official Symbol    CTSC [Similar Products]
 NCBI Official Synonym Symbols   
JP; HMS; JPD; PLS; CPPI; DPP1; DPPI; PALS; DPP-I; PDON1
[Similar Products]
 NCBI Protein Information    dipeptidyl peptidase 1
 UniProt Protein Name    Dipeptidyl peptidase 1
 UniProt Synonym Protein Names   
Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI
 Protein Family    Cathepsin
 UniProt Gene Name    CTSC [Similar Products]
 UniProt Synonym Gene Names    CPPI; DPP-I; DPPI [Similar Products]
 UniProt Entry Name    CATC_HUMAN
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 NCBI Summary for CTSC    This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
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 UniProt Comments for CTSC    CTSC: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Defects in CTSC are a cause of Papillon-Lefevre syndrome (PLS); also known as keratosis palmoplantaris with periodontopathia. PLS is an autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Defects in CTSC are a cause of Haim-Munk syndrome (HMS); also known as keratosis palmoplantaris with periodontopathia and onychogryposis or Cochin Jewish disorder. HMS is an autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Defects in CTSC are a cause of aggressive periodontititis type 1 (AP1); also known as juvenile periodontitis (JPD) and prepubertal periodontitis (PPP). AP1 is characterized by severe and protracted gingival infections, leading to tooth loss. AP1 inheritance is autosomal dominant. Belongs to the peptidase C1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; EC 3.4.14.1; Protease

Chromosomal Location of Human Ortholog: 11q14.2

Cellular Component: endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular space; Golgi membrane; lysosome; membrane

Molecular Function: apoptotic protease activator activity; chaperone binding; chloride ion binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; phosphatase binding; protein binding; protein self-association; serine-type endopeptidase activity

Biological Process: aging; apoptosis; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; immune response; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; proteolysis; proteolysis involved in cellular protein catabolic process; response to organic substance; T cell mediated cytotoxicity

Disease: Haim-munk Syndrome; Papillon-lefevre Syndrome; Periodontitis, Aggressive, 1
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 Research Articles on CTSC    1. Results identify a missense mutation in CTSC gene that segregate within a family with Papillon-Lefevre syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CTSC antibodyPathways associated with anti-CTSC antibody
 Reference Product  PubMed Publications
 CTSL1 antibody  >1 publications with CTSC and CTSL1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
Diseases associated with anti-CTSC antibodyOrgans/Tissues associated with anti-CTSC antibody
 Disease Name  Pubmed Publications
 Papillon-Lefevre Disease Antibodies  >53 publications with CTSC and Papillon-Lefevre Disease
 Periodontal Diseases Antibodies  >22 publications with CTSC and Periodontal Diseases
 Aggressive Periodontitis Antibodies  >16 publications with CTSC and Aggressive Periodontitis
 Inflammation Antibodies  >11 publications with CTSC and Inflammation
 Disease Models, Animal Antibodies  >10 publications with CTSC and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with CTSC and Cardiovascular Diseases
 Disease Progression Antibodies  >6 publications with CTSC and Disease Progression
 Liver Diseases Antibodies  >5 publications with CTSC and Liver Diseases
 Brain Diseases Antibodies  >5 publications with CTSC and Brain Diseases
 Necrosis Antibodies  >4 publications with CTSC and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with CTSC and Blood
 Skin Antibodies  >14 publications with CTSC and Skin
 Bone Antibodies  >12 publications with CTSC and Bone
 Brain Antibodies  >9 publications with CTSC and Brain
 Lung Antibodies  >7 publications with CTSC and Lung
 Bone Marrow Antibodies  >6 publications with CTSC and Bone Marrow
 Liver Antibodies  >6 publications with CTSC and Liver
 Heart Antibodies  >5 publications with CTSC and Heart
 Mouth Antibodies  >5 publications with CTSC and Mouth
 Kidney Antibodies  >4 publications with CTSC and Kidney
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