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anti-CTSH antibody :: Rabbit Cathepsin H Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8229166
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin H (CTSH), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Cathepsin H Antibody

 Product Synonym Names    CPSB; Pro-cathepsin H
 Product Gene Name   

anti-CTSH antibody

[Similar Products]
 Antibody/Peptide Pairs    Cathepsin H peptide (MBS8211475) is used for blocking the activity of Cathepsin H antibody (MBS8229166)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116820
 3D Structure    ModBase 3D Structure for P09668
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of Cathepsin H protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin H. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CTSH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CTSH antibody

   Rabbit polyclonal antibody to Cathepsin H
 Applications Tested/Suitable for anti-CTSH antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CTSH antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200)
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 Western Blot (WB) of anti-CTSH antibody    Western blot analysis of Cathepsin H expression in Jurkat (A), K562 (B), mouse kidney (C), PC12 (D) whole cell lysates.
anti-CTSH antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CTSH antibody    Immunohistochemical analysis of Cathepsin H staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-CTSH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CTSH. It may not necessarily be applicable to this product.
 NCBI GI #    23110955
 NCBI GeneID    1512
 NCBI Accession #    NP_004381.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004390.3 [Other Products]
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 UniProt Primary Accession #    P09668 [Other Products]
 UniProt Secondary Accession #    Q96NY6; Q9BUM7; B2RBK0 [Other Products]
 UniProt Related Accession #    P09668 [Other Products]
 Molecular Weight    37,394 Da
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 NCBI Official Full Name    pro-cathepsin H preproprotein
 NCBI Official Synonym Full Names    cathepsin H
 NCBI Official Symbol    CTSH [Similar Products]
 NCBI Official Synonym Symbols   
ACC4; ACC5; CPSB; ACC-4; ACC-5; minichain
[Similar Products]
 NCBI Protein Information    pro-cathepsin H
 UniProt Protein Name    Pro-cathepsin H
 Protein Family    Pro-cathepsin
 UniProt Gene Name    CTSH [Similar Products]
 UniProt Synonym Gene Names    CPSB [Similar Products]
 UniProt Entry Name    CATH_HUMAN
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 NCBI Summary for CTSH    The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
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 UniProt Comments for CTSH    CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: extracellular space; lysosome; acrosome; cytosol; outer dense fiber

Molecular Function: peptidase activity; protein binding; HLA-A specific activating MHC class I receptor activity; protein self-association; serine-type endopeptidase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; caspase activator activity; aminopeptidase activity; kininogen binding; cysteine-type peptidase activity

Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; membrane protein proteolysis; proteolysis; antigen processing and presentation; positive regulation of angiogenesis; positive regulation of cell proliferation; zymogen activation; spermatogenesis; metanephros development; surfactant homeostasis; immune response-regulating signal transduction; T cell mediated cytotoxicity; negative regulation of apoptosis; positive regulation of cell migration
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 Research Articles on CTSH    1. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CTSH antibodyPathways associated with anti-CTSH antibody
 Reference Product  PubMed Publications
 CST3 antibody  >17 publications with CTSH and CST3
 CSTA antibody  >7 publications with CTSH and CSTA
 CSTB antibody  >7 publications with CTSH and CSTB
 CTSD antibody  >6 publications with CTSH and CTSD
 C1QTNF6 antibody  >1 publications with CTSH and C1QTNF6
 INS antibody  >1 publications with CTSH and INS
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
Diseases associated with anti-CTSH antibodyOrgans/Tissues associated with anti-CTSH antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >24 publications with CTSH and Nervous System Diseases
 Inflammation Antibodies  >18 publications with CTSH and Inflammation
 Disease Models, Animal Antibodies  >18 publications with CTSH and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >13 publications with CTSH and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >9 publications with CTSH and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >9 publications with CTSH and Adenocarcinoma
 Heart Diseases Antibodies  >8 publications with CTSH and Heart Diseases
 Lung Neoplasms Antibodies  >8 publications with CTSH and Lung Neoplasms
 Kidney Diseases Antibodies  >7 publications with CTSH and Kidney Diseases
 Liver Diseases Antibodies  >6 publications with CTSH and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >75 publications with CTSH and Blood
 Liver Antibodies  >55 publications with CTSH and Liver
 Thyroid Antibodies  >35 publications with CTSH and Thyroid
 Kidney Antibodies  >35 publications with CTSH and Kidney
 Lung Antibodies  >27 publications with CTSH and Lung
 Muscle Antibodies  >25 publications with CTSH and Muscle
 Brain Antibodies  >24 publications with CTSH and Brain
 Skin Antibodies  >18 publications with CTSH and Skin
 Spleen Antibodies  >14 publications with CTSH and Spleen
 Bone Antibodies  >12 publications with CTSH and Bone
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